The Role of Inflammation in the Etiology of Precancerous Lesions, Carcinogenesis and Cancer Treatment

Dear Colleagues,

Inflammatory processes are one of the essential etiological factors in cancers. The etiology of many types of cancer is associated with bacterial and viral infection. After stimulation, primary and secondary inflammation cytokines, chemokines, inflammasome proteins, growth factors secreted by inflammatory cells (dendrocytes, mast cells, fibroblast, monocytes, macrophages, endothelial cells, melanocytes, lymphoid cells ILC1, ILC3 and also different types of lymphocytes: CD4 (TH17, Th22, Th1, Th2), NKT, gδ T cells, CD8 Tcells, Treg cells) are involved in the initiation, progression and metastase development of tumors and can also suppress immune system.

The biological drugs currently utilized in clinic represent a double-edged sword, with both beneficial and detrimental effects. Monoclonal antibodies (anti TNF-α, anti- interleukin and anti- specific for the inflammatory cells receptors) and therapies based on cytostatic and phototherapeutic methods (for example PUVA therapy) have a profound effect on the immune system and can suppress surveillance and its anti-cancer functions. They also exacerbate the endocrine tissue system, as the source of neuropeptides and neurohormones can be involved in cancer progression and metastasis.

In this Special Issue, supervised by the Guest Editor group and additionally supported by Prof. Piotr Wierzbicki (Medical University of Gdańsk), we encourage authors to publish articles that discuss the role of inflammatory processes, induced by endogenous factors (stress, hormones, autoantibodies), exogenous factors (viruses, bacteria) and epigenetic phenomena (ln RNA, miRNA, promoter genes methylation, posttranscriptional histone modification), in the progression and metastasis of tumors; this particularly includes renal and urogenital system pathologies, pancreatic cancer, breast cancer, mastocytosis, colorectal cancer, upper gastrointestinal cancer, nonmelanomas skin cancer and melanomas, and precancerous lesions, including precancerous skin lesions.

In additional, we strongly encourage the submission of research on conventional and biological drugs, immunotherapy, and immunonutrition. We hope to explore their role in the control and modulation of the inflammatory processes at the basis of cancerous and precancerous skin lesions. Your contributions to these topics will undoubtedly enrich the scientific discourse in this field.

Dr. Boguslaw Nedoszytko
Prof. Dr. Leszek Kalinowski
Prof. Dr. Luigi Marano
Guest Editors

Manuscript Submission Information

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• inflammation cascade in cancer initiation, progression and metastasis
• inflammasome proteins, glycation, NOS isoforms, nitric oxide, oxidative and nitroxidative stress, DAMP, TLR, ferroptosis and necrosis in cancer etiology
• COVID-19 infection, cancer and neurodegenerative isorders
• inflammatory cells and cacer
• primary and secondary inflammation cascade cytokines (IL-1, TNFα, IL-18, IL-8, IL-6), chemokines, and growth factors in cancer
• noncoding RNA and other epigenetic mechnisms in cancer
• oxidative/nitroxidative-dependent cell signaling
• breast, prostate, urogenital, renal, thyroiccolon and esophago-gastric cancers, melanomas, skin diseases associated with cancer
• oncogenes, supressor genes, apoptosis, gene dysfunction and cancer
• metabolomic, microbiotic, proteomic and genomic changes in cancer
• biological drugs in inflammatory diseases and cancer treatment
• effects of immunonutrition and microbiotic modulators on the inflammatory infiltration of the tumor microenvironment
• neurodegenerative changes in cancer and after cancer treatmet
• the regulatory feedback of inflammatory signaling and telomere/telomerase complex dysfunction in carcinogenesis and chronic inflammatory diseases

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22. Repczyńska et al. "The role of inflammatory process in pathogenesis of Fanconi anaemia - a review"
23. Kalinowski et al. "(To be done)"
24. Slominski et al. "(To be done)"
25. Niedoszytko et al. "The role of exhaled breathcondensate in the diagnosis of chronic inflammatory and neoplastic diseases of the respiratory tract"
26. Szydłowski et al. "Role of inflammatory and epigenetic factors in pathogenesis of parotid gland tumors"