The Role of Autophagy in Developmental Biology with Model System
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 219
Special Issue Editors
Interests: molecular viral pathogenesis and potential drugs screening; zebrafish as a model in basic embryonic development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Macroautophagy (so-called autophagy) is a degradation pathway whereby cytosolic double-membrane-bound compartments termed autophagosomes engulf cytoplasmic constituents such as sub-cellular organelles and microbial pathogens, and target them for lysosomal degradation. Several genes (autophagy-related genes; ATGs) have been described as regulators of autophagy, many of them being evolutionarily conserved from yeast to mammals. The study of autophagy-defective model systems has made it possible to highlight the importance of correctly functioning autophagic machinery in the development of nvertebrates as, for example, during the complex events of zebrafish brain formation. In the eukaryotic cells autophagy seems to be crucial during embryogenesis by acting in tissue remodeling that there is a close interplay between autophagy and the processes of cell death, metabolism, proliferation and differentiation that determine the tissue development and genetic defected and diseases. Whether and how the autophagic machinery (ATG-dependent) or signaling (Akt/mTOR/ULK1) selectively recognizes and triggering during early development remains largely unexplained.
Prof. Dr. Jiann-Ruey Hong
Dr. Jen-Leih Wu
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- zebrafish
- Drosophila
- C. elegans
- autophagy
- autophagy-related genes
- cell death
- gene knockout
- metabolism
- stress forces
- translational medicine
