Galectins (Gals)
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 15 July 2024 | Viewed by 110
Special Issue Editor
Interests: protein structure–function relationship; protein–protein interactions; thermophoresis; isothermal titration calorimetry; biophysical characterization; static and dynamic light scattering; protein folding/unfolding
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Galectins are a family of soluble proteins expressed in a broad range of animal species and present in various cell types. All these proteins share a common Carbohydrate Recognition Domain (CRD), which is directly involved in carbohydrate binding, in particular to b-galactose residues. The CRD, highly conserved in the family, consists of approximately 130 amino acids organized in a typical b-sandwich fold. The Galectins on the base of their CRD structure have been classified into three groups: proto, tandem repeat, and chimeric galectins. Galectins are mammalian lectins involved in a variety of roles, including immune regulation, cancer cell growth, and apoptosis. Galectin research is becoming increasingly important in recent years thanks to the different roles they can play in many applications as disease biomarkers, therapeutic agents, and drug targets. Given their multiple roles in infectious diseases, Galectins have emerged as a modern drug target in a broad range of infections. Many multidisciplinary approaches, encompassing molecular modeling and design, synthetic, and biological chemistry as well as biological characterization, emphasize the needs to identify and to valid new synthetic and natural molecules with a specific biological activity as the modulators of Galectins in cancer and/or infection treatments.
Dr. Luciano Pirone
Guest Editor
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Keywords
- Galectin
- inhibitors
- cancer
- inflammation
- glycans
- drug design
- modeling
- biomarkers
