Advances in Breast and Ovarian Cancers: Pathogenetic Mechanisms, DNA Damage and Advanced Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 225
Special Issue Editor
Special Issue Information
Dear Colleagues,
Breast and ovarian cancers represent two of the most common malignancies in women. Patients who present with a higher stage of either cancer have been shown to have a much higher risk of recurrence over time. The need for earlier detection remains key in order to prevent a worse prognosis and higher chances of recurrence. Therefore, understanding the pathogenetic mechanisms involved in carcinogenesis as well as tumor progression is highly relevant. One such mechanism is DNA damage. Research in recent years has led to the approval of PARP inhibitors that take advantage of mutations in DNA repair mechanisms for both breast and ovarian cancers. Despite these recent advances, there are still a number of individuals who develop resistance to these therapeutics over time. This represents the need for further research into advanced therapies that then need to take advantage of DNA damage and/or repair mechanisms to aid in the treatment of these cancers.
This Special Issue of IJMS will welcome original research and review articles with the aim of providing an overview of advances in breast and ovarian cancer with an emphasis on pathogenetic mechanisms, DNA damage and advanced therapies.
Dr. Kevin Lee is a good scientist (Topical Advisory Panel Member in IJMS), who will assist Prof. Natalie R. Gassman in managing this Special Issue.
Dr. Natalie Gassman
Guest Editor
Manuscript Submission Information
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Keywords
- ovary
- ovarian cancer
- breast cancer
- DNA damage
- DNA repair
- advanced therapies
