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Special Issue "Pathways in Development and Disease: The Role of RNA Regulation in Biological and Pathological Events"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 10 October 2023 | Viewed by 137

Special Issue Editors

1. Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal
2. Coimbra Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal
3. Department of Surgery, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal
Interests: RNA; human disease; cancer; diagnosis; therapy; development
Department of Pathology, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal
Interests: RNA; human disease; cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Human diseases are very heterogeneous but may be clustered and congenital, inflammatory/degenerative, and oncologic. Many factors take place in this process, but a key player is RNA.

RNA is pivotal in the regulation of cellular events, acting in the post-transcriptional phase, providing checkpoints in cellular functions and gene regulation. The improvement in scientific knowledge has highlighted this role, providing more and more data, from function to therapy. Today, we know that RNA molecules are exposed to multiple posttranscriptional processes that affect gene expression, namely translation, transport, degradation, and splicing, among others. Therefore, RNA dysregulation affects different biological processes in human diseases.

As the landscape of RNA biology keeps evolving and providing us with interesting answers, it also introduces deep and intricate questions on how to integrate knowledge and apply it in therapeutic approaches. Selective changes in RNA are associated with biological adaptations to an everchanging environment, and its comprehension will be fundamental to the design of targeted therapies in order to overcome the burden of diseases.

In this Special Issue, we invite publishers to present their excellent research/reviews on RNA and diseases, hoping to improve our knowledge and understanding of this subject.

Suggestion of topics to be handled by this Special Issue:

  • Role of RNA post-transcriptional modification in cancer;
  • RNA role in development;
  • Interaction between human RNA and virus RNA in virus-mediated human disease;
  • Diagnostic applications of RNA in cancer;
  • Extracellular small noncoding RNA in cancer;
  • RNA-based therapies in human disease.

Prof. Dr. Guilherme Tralhão
Dr. Rui Caetano Oliveira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • RNA
  • human disease
  • cancer
  • diagnostic
  • therapy
  • development

Published Papers

This special issue is now open for submission.
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