RNA-Based Diagnostics and Therapeutics for Colorectal Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 October 2024 | Viewed by 39
Special Issue Editor
Interests: colorectal cancer; non-coding RNAs; RNAi-based therapy; biomarkers
Special Issue Information
Dear Colleagues,
RNA was originally labeled as a messenger (mRNA) that mediates the flow of genetic information from DNA to protein. However, recent advances in sequencing technology have led to the discovery of a plethora of non-protein-coding RNAs (ncRNAs), which challenges this dogma. Indeed, a comprehensive analysis of human transcriptomics data revealed that approximately 75% of the genome is capable of being transcribed, thus producing a great variety of RNA species, including mRNAs, microRNAs (miRNAs), ribosomal RNAs (rRNAs), transfer RNAs (tRNAs), small nuclear RNAs (snRNAs), and long non-coding RNAs (lncRNAs), among others. Naturally, this heterogeneity yields complex and specific expression patterns that support the timely execution of a wide range of functions. Interestingly, these features highlight the potential of RNA molecules to serve as a comprehensive toolbox to detect and monitor disease-dependent changes, as well as find disease-specific vulnerabilities.
This Special Issue provides a platform to review the current state and disseminate recent findings related to the development of RNA-based diagnostic and therapeutic tools in the context of colorectal cancer.
Dr. Nicolas Leveille
Guest Editor
Manuscript Submission Information
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Keywords
- targeted therapy
- RNAi
- CRISPR-Cas technology
- diagnostic
- liquid biopsy
- extracellular vesicles
- biomarkers
