The Molecular and Cellular Aspects of Insulin Resistance
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 20 September 2024 | Viewed by 332
Special Issue Editors
Interests: cell signaling and hypertension; cell signaling and insulin resistance; metabolic syndrome and diabetes; cell signaling and stress
Interests: calcium handling proteins; metabolic syndrome and diabetes; metabolic alterations
Special Issue Information
Dear Colleagues,
Insulin resistance is a systemic disorder in which cells fail to respond to normal circulating insulin levels. Under this condition, the biological actions of insulin on hepatic, muscular, and adipose tissues, such as glucose uptake and the synthesis of glycogen, lipids, and proteins, are altered. Experimental and clinical trials have provided evidence that insulin resistance in metabolic tissues constitutes a hallmark of metabolic dysfunction, mainly induced by obesity. This peripheral insulin resistance causes pancreatic β-cells to secrete more insulin in a process known as compensatory hyperinsulinemia. However, together with insulin resistance, there is reduced β-cell function, resulting in sustained hyperglycemia and type 2 diabetes mellitus. At the molecular level, insulin resistance is the consequence of insulin signaling impairment resulting from mutations or post-translation modification of the insulin receptor itself or any of its downstream effectors, including the insulin receptor substrate, PI3K, and Akt.
Despite being a subject widely studied from a molecular and clinical perspective, insulin resistance continues to be an area of study that poses new challenges in basic and clinical research, such as its impact on metabolic syndrome, inflammation, neuronal, cognitive, and cardiovascular disorders, among others.
We invite scientists working on this topic to contribute to this Special Issue. Original research articles or reviews on all aspects of the molecular and cellular mechanisms of insulin resistance and its implications in the development of pathologies associated with inflammatory processes, metabolism, cardiovascular, neurological, cognitive disorders, and cancer, among others, will be welcome.
Prof. Dr. Jesús Alberto Olivares-Reyes
Prof. Dr. Angélica Rueda
Guest Editors
Manuscript Submission Information
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Keywords
- insulin resistance
- insulin receptor
- IRS
- Akt
- PI3K
- protein phosphorylation
- protein dephosphorylation
- inflammation
- metabolic syndrome
- cardiometabolic syndrome
- diabetic cardiomyopathy
