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The Molecular and Cellular Aspects of Insulin Resistance

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 345

Special Issue Editors

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Guest Editor
Laboratory of Signal Transduction, Department of Biochemistry, Center for Research and Advanced Studies of the National Polytechnic Institute, Cinvestav-IPN, Mexico City 07360, Mexico
Interests: cell signaling and hypertension; cell signaling and insulin resistance; metabolic syndrome and diabetes; cell signaling and stress

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Guest Editor
Laboratory of Cardiovascular Biochemistry and Physiology, Department of Bio-Chemistry, Center for Research and Advanced Studies of the National Polytechnic Institute, Cinvestav-IPN, Mexico City 07360, Mexico
Interests: calcium handling proteins; metabolic syndrome and diabetes; metabolic alterations

Special Issue Information

Dear Colleagues,

Insulin resistance is a systemic disorder in which cells fail to respond to normal circulating insulin levels. Under this condition, the biological actions of insulin on hepatic, muscular, and adipose tissues, such as glucose uptake and the synthesis of glycogen, lipids, and proteins, are altered. Experimental and clinical trials have provided evidence that insulin resistance in metabolic tissues constitutes a hallmark of metabolic dysfunction, mainly induced by obesity. This peripheral insulin resistance causes pancreatic β-cells to secrete more insulin in a process known as compensatory hyperinsulinemia. However, together with insulin resistance, there is reduced β-cell function, resulting in sustained hyperglycemia and type 2 diabetes mellitus. At the molecular level, insulin resistance is the consequence of insulin signaling impairment resulting from mutations or post-translation modification of the insulin receptor itself or any of its downstream effectors, including the insulin receptor substrate, PI3K, and Akt.

Despite being a subject widely studied from a molecular and clinical perspective, insulin resistance continues to be an area of study that poses new challenges in basic and clinical research, such as its impact on metabolic syndrome, inflammation, neuronal, cognitive, and cardiovascular disorders, among others.

We invite scientists working on this topic to contribute to this Special Issue. Original research articles or reviews on all aspects of the molecular and cellular mechanisms of insulin resistance and its implications in the development of pathologies associated with inflammatory processes, metabolism, cardiovascular, neurological, cognitive disorders, and cancer, among others, will be welcome.

Prof. Dr. Jesús Alberto Olivares-Reyes
Prof. Dr. Angélica Rueda
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • insulin resistance
  • insulin receptor
  • IRS
  • Akt
  • PI3K
  • protein phosphorylation
  • protein dephosphorylation
  • inflammation
  • metabolic syndrome
  • cardiometabolic syndrome
  • diabetic cardiomyopathy

Published Papers

This special issue is now open for submission.
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