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Molecular Insights into Type 2 Diabetes and Its Complications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 158

Special Issue Editor

Department of Medical and Surgical Sciences, University Magna Græcia, 88100 Catanzaro, Italy
Interests: obesity; type-2 diabetes; metabolic syndrome; endothelial dysfunction; hypertension; target organ damage
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Type 2 diabetes is on the rise and has become a widespread epidemic in recent years. It is one of the leading causes of cardiovascular disease, blindness, end-stage renal disease, and non­traumatic lower-limb amputations, leading to growing social and clinical burdens globally. As a result, an enriched understanding of the pathogenesis of type 2 diabetes along with attempts to sort out and carry out effective approaches to prevent or treat type 2 diabetes or its macro- and micro-vascular complications are of paramount importance.

A large body of evidence has well documented that metabolic defects, such as islet β-cell dysfunction, reduced incretin response, and impaired autonomic function, are commonly observed in patients with type 2 diabetes. They may drive the development of type 2 diabetes and contribute to the increased risk of diabetes-related complications. The aim of this Special Issue is to promote the latest research in physiology that focuses on the metabolic defects underlying the onset of type 2 diabetes or its complications, with a particular focus on the association between type 2 diabetes mellitus and cardiovascular disease, with direct or indirect connections to the clinical applications and/or practices. We also plan to advance our knowledge about the effectiveness of lifestyle modifications, such as increased physical activity or reduced sedentary time, for managing type 2 diabetes. We will focus on the mechanisms that mediate alterations of metabolic defects induced by lifestyle modifications, wishing to provide interactions and/or communications between basic and clinical researchers. Manuscripts in the form of original articles, reviews, and commentaries are welcome for submission to this Special Issue.

Prof. Dr. Maria Perticone
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • diabetes
  • metabolic defects
  • β-cell function
  • dietary intervention
  • physical exercise

Published Papers

This special issue is now open for submission.
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