Drug Design and Development for Neurological Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 28 June 2024 | Viewed by 175
Special Issue Editors
Interests: organic and medicinal chemistry; computational chemistry and molecular modeling of GAT, MAT, VGIC; predictive modelling of detailed mechanisms of action and pharmacological effec-tiveness of biologically active compounds and chemical reaction pathways; neuropharmacology; cardiovascular; safety pharmacology
Special Issues, Collections and Topics in MDPI journals
Interests: clinical and experimental pharmacology; cardiovascular pharmacology; internal medicine; en-dothelial function; vascular smooth muscle function; direct oral anticoagulants; therapeutic drug monitoring; antiplatelets agents
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurological disorders encompass a wide range of conditions that impact the neurological system, which comprises the brain, spinal cord and peripheral nerves. These disorders are intricate and frequently have a genetic basis. Manifestations of the condition can vary, including severe and prolonged discomfort, alterations in cognitive and behavioral patterns, as well as difficulties in motor functions. These illnesses can profoundly influence individuals, potentially resulting in life-threatening conditions and detrimentally impacting their quality of life.
Recent research has made notable progress in the advancement of medications for the treatment of neurological illnesses. Observing the efficacy of structure-based drug design and the therapeutic potential of nucleic acid-based therapeutics, such as plasmid DNA and NFκB decoy, in the treatment of neurological disorders is intriguing. Several writers have highlighted the significance of distinct strategies for aberrant protein folding and aggregation in neurodegenerative illnesses, while other researchers have concentrated on the utilization of polymeric nanoparticles for medication administration in these diseases. Research that specifically examines the process of repurposing existing medications for new uses in treating neurodegenerative illnesses is also deemed significant. These studies emphasize the diverse and promising approaches employed in the design and advancement of treatments for neurological disorders.
This Special Issue aims to bring together research on all aspects of molecular modeling in the neurotransmission phenomenon. It will contain high-quality research articles and review articles summarizing the state of the art in a specific area of this research field.
This Special Issue is supervised by Dr. Alicja Nowaczyk and assisted by our Topical Advisory Panel Member (Dr. Łukasz Fijałkowski, Nicolaus Copernicus University).
Prof. Dr. Alicja Nowaczyk
Prof. Dr. Grzegorz Grześk
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neurological disorders and their therapies
- molecular modeling
- synthesis and structural analysis
- neurotransmitters ligands
- mechanism of action
- drug repurposing
