Cell Pathways Underlying Neuronal Differentiation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 August 2024 | Viewed by 76
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cell differentiation in mammals represents a critical process during which totipotent or pluripotent cells progressively acquire morphological and biochemical features of specific mature phenotypes. This process mainly occurs during embryonic development, while it drastically reduces in adult life. This is especially true for neurons. In fact, although the persistence of neurogenic niches in adult life has been demonstrated and adult neurogenesis has been described in experimental models, the occurrence of neurogenesis in humans still remains controversial, and the generation of new neurons in an adult organism represents a challenging new frontier for regenerative medicine. In recent years, advances in methodological and technological procedures have allowed new treatments to be developed, capable of inducing stem-like neural progenitor cells and even somatic cells to reprogram their differentiation in fate and convert them into neurons.
The present Special Issue aims to collect the more recent research data obtained in experimental models both in vivo and in vitro, which provide new insights regarding the molecular mechanisms and cell pathways that are key to directing undifferentiated, stem-like neural cells toward a neuronal phenotype. These findings, apart from being essential to increasing our knowledge of neurobiology, might contribute to the development of new therapeutic strategies in order to counteract several human neuronal pathologies such as brain and spinal cord injury and brain tumors.
Dr. Michela Ferrucci
Guest Editor
Manuscript Submission Information
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Keywords
- neural progenitor cells
- neuronal cell lines
- induced pluripotent stem cells
- neuronal phenotype
- brain tumor cells
