Molecular Insights into Development and Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (30 March 2024) | Viewed by 571
Special Issue Editors
Interests: transcription factors; Grainyhead-like; skin cancer; brain cancer; mammalian embryonic development; lung morphogenesis; zebrafish embryonic development; craniofacial development; brain development; neurogenesis; epidermal disorders; wound healing
Special Issues, Collections and Topics in MDPI journals
Interests: squamous cell carcinoma; skin; head and neck; mouse models; oncogenic networks; prevention; treatment; biomarkers
Special Issues, Collections and Topics in MDPI journals
Interests: transcription factors; Grainyhead-like; regulation of gene expression; oncogenes; tumor suppressors; drug targets; phosphorylation; post-translational modifications; skin cancer; renal cancer; somatic mutations in cancer; polymorphisms including single nucleotide polymorphisms; mammalian embryonic development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Normal embryonic development is governed by signaling pathways that control a myriad of processes, ranging from cell division, migration and differentiation to organ formation. These pathways are often co-opted and de-regulated in common diseases of adulthood, including the progression of cancer. Many parallels exist between the normal cellular process required for the establishment of an embryo (such as asymmetric cell division in stem cells, epithelial to mesenchymal transitions in organ establishment, and formation of the vascular system required) with identical pathways that drive tumor initiation and progression. In effect, tumor growth can, in many cases, be thought of as the aberrant establishment of a new “organ” (Gerlitz et al., EMBO Reports 9: 730-734), utilizing and corrupting precisely the same signaling pathways required for normal growth. This Special Issue is devoted to understanding these parallels; by determining the normal pathways of tissue and organ establishment, we can better understand the consequences of their deregulation in the context of cancer development.
Dr. Seb Dworkin
Dr. Charbel Darido
Dr. Tomasz Wilanowski
Guest Editors
Manuscript Submission Information
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Keywords
- development
- proliferation
- embryogenesis
- angiogenesis
- epithelial–mesenchymal transition (EMT)
- stem cells
- migration
- differentiation
- de-differentiation
