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Novel Molecular Insights into the Most Common Muscular Dystrophy, Motor Neuron and Neuromuscular Junction Diseases

 

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 39

Special Issue Editor


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Guest Editor
Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University, Bryan, TX 77807, USA
Interests: neurobiology; synapse formation and maintenance; synaptic glia; neuromuscular junction; neuromuscular diseases

Special Issue Information

Dear Colleagues,

Neuromuscular disorders (NMDs) are relatively rare diseases, characterized by symptoms of muscle weakness and wasting, which originate in failures within muscles themselves but also in the neurons, nerves, and synapses that control their contraction. Among the hundreds of NMDs, well-known exemplars, whose primary targets are specific components of the motor unit, include amyothropic lateral sclerosis (ALS), Duchenne muscular dystrophy (DMD), myasthenia gravis (MG), and congenital myasthenic syndromes (CMSs), principally targeting motor neurons, skeletal and cardiac muscle, and the neuromuscular junction (NMJ), respectively. Many an NMD, including ALS, DMD, and some CMSs, are fatal, currently lacking effective treatments aimed at the root cause of the diseases, not their symptoms; however, through the relentless efforts of researchers, advocates, and patients, the symbiotic relationship between clinical and basic research continues to generate genetic and pharmacological approaches with therapeutic potential in reducing patient functional decline, increasing survival, and improving the quality of life. Although promising, these novel interventions face challenges that need to be overcome in further research.

This Special Issue seeks contributions, original research, and review articles that address recent advances and challenges in understanding the basic mechanisms of neuromuscular molecular and cellular biology, disease etiology, pathogenesis, diagnostics, and therapeutics germane to ALS, DMD, MG, and CMSs in all of their forms.

Dr. Mendell Rimer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ALS
  • DMD
  • CMS
  • NMJ
  • motor neuron disease
  • muscular dystrophy
  • neuromuscular junction
  • motor neuron
  • skeletal muscle

Published Papers

This special issue is now open for submission.
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