Neuromodulation in Neurological and Psychiatric Disorders: Clinical, Physiological and Molecular Evidence
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 April 2024 | Viewed by 195
Special Issue Editor
Special Issue Information
Dear Colleagues,
Neuromodulation consists of a variety of invasive and non-invasive therapies for patients with severe neurologic and psychiatric disorders. As an established invasive procedure, deep brain stimulation (DBS) is applied for a variety of pharmacologically resistant neurological and psychiatric disorders. The renaissance of deep brain stimulation (DBS) for essential tremors in 1987 and subsequently for Parkinson’s disease (PD) in Grenoble, France, led only a decade later to DBS for psychiatric diseases, with the first reports published on DBS for obsessive compulsive disorder (OCD) and for Gilles de la Tourette’s syndrome. DBS for the treatment of refractory depression was pioneered shortly after in 2005. Since then, more than 260,000 patients worldwide have been treated with DBS. The indications for DBS have broadened rapidly during the last few decades to other pathologies such as eating disorders, chronic pain, dementia and epilepsy. The U.S. Food and Drug Administration (FDA) approved DBS for essential tremors in 1997, for PD in 2002, for dystonia in 2003 and for OCD in 2009 (under a Humanitarian Device Exemption). Further promising neuromodulation therapies include epidural motor cortex stimulation (MCS) for neuropathic and phantom limb pain, as well as vagus nerve stimulation (VNS) for the treatment of pharmacological refractory epilepsy. Electroconvulsive therapy (ECT), a non-invasive therapy, is applied for severe major depressive disorder, bipolar affective disorder or schizophrenia. Other non-invasive therapies are transcranial electrical stimulation (TES) and transcranial magnetic stimulation (TMS), used for a variety of neurological and psychiatric conditions. This Special Issue aims to review the latest evidence on the effectiveness and safety of these neuromodulation modalities in neurological and psychiatric disorders and will examine the potential underlying molecular mechanisms of the applied techniques.
Dr. Christian Saleh
Guest Editor
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Keywords
- neuromodulation
- deep brain stimulation
- transcranial magnetic stimulation
- electroconvulsive therapy
- vagus nerve stimulation
- neurological disorders
- psychiatric disorders
- molecular mechanisms
- safety
