Macrophage Polarization: Learning to Manage It 4.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 18
Special Issue Editor
Interests: inflammation and innate immunity; macrophages polarization; osteoimmunology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Macrophages are crucial components of innate immunity. They possess high plasticity and the ability to differentiate in response to numerous stimuli. The physiological and/or pathological conditions characterize the environment in which the macrophages reside and determine their heterogeneity. There is a plethora of different specialized functional phenotypes, among which inflammatory (M1) and reparative (M2) subtypes are proposed, which are almost exactly opposite to each other. Two key cytokines, IFN-γ and TNF-α, are responsible for M1, or classical activation, while the alternate M2 activation is mediated mainly by IL-4 and IL-13. Interestingly, microRNAs and some immunomodulators are critical regulators of macrophage polarization. The link with many human diseases and infections, including cancer, autoimmunity and periodontitis, is to be found in the dysregulation of macrophage plasticity. Furthermore, recent studies on naturally occurring compounds emphasize their regulatory effects on macrophage polarization, suggesting that some of them could be promising for the treatment of sensitive diseases.
This Special Issue aims to cover all areas of molecular research, but is not limited to this, as it may include clinical studies with biomolecular experiments.
Dr. Nadia Lampiasi
Guest Editor
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Keywords
- macrophages
- macrophage plasticity
- macrophage polarization
- innate immunity
- IFN-γ
- TNF-α
- immunomodulators
- diseases
- homeostasis
- inflammation
- cancer
Related Special Issues
- Macrophage Polarization: Learning to Manage It in International Journal of Molecular Sciences (13 articles)
- Macrophage Polarization: Learning to Manage It 2.0 in International Journal of Molecular Sciences (12 articles)
- Macrophage Polarization: Learning to Manage It 3.0 in International Journal of Molecular Sciences (7 articles)
