Molecular Basis and Therapy of Optic Neuropathies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 July 2024 | Viewed by 271
Special Issue Editors
Interests: optic neuropathies; optic disc drusen; idiopathic intracranial hypertension; ischemic optic neuropathy; oculomics; optical coherence tomography; advanced ocular imaging; artificial intelligence
Interests: big data; data curation; datasets; health data research; idiopathic intracranial hypertension; ischemic optic neuropathy; giant cell arteritis; oculomics; optical coherence tomography; optic neuropathies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Optic neuropathy is a frequent cause of visual loss that can have implications not only for sight but also for systemic health. There is a wide range of aetiologies, including demyelinating, inflammatory, ischemic, traumatic, compressive, toxic, nutritional, and hereditary causes. Understanding the basic molecular mechanisms of disease processes affecting the optic nerves and the anterior afferent visual pathway is essential for developing targeted and effective therapy. Currently, the molecular basis for many of these underlying diseases is being elucidated, in part due to rapidly advancing imaging technologies but also as a result of the work of dedicated, focused research groups acquiring accumulated evidence for novel disease mechanisms.
There are many examples of the evolving understanding of the diseases that affect the optic nerves: The defining of the clinical features and treatments of the neuromyelitis optica spectrum disorder (NMOSD) optic neuritis and myelin oligodendrocyte glycoprotein (MOG) optic neuritis versus multiple sclerosis (MS) optic neuritis. Research to restore the mitochondrial electron transport chain of the retinal ganglion cells in Leber’s hereditary optic neuropathy has led to unique findings of drug effects in the contralateral eye. Compressive optic neuropathies from tumors or raised intracranial pressure continue to educate us on the patterns of loss seen on structural imaging and what this means for the functional final visual outcome. Ischemic optic neuropathy has historically been resistant to treatments, and it is possible that advanced imaging of the optic nerve will lead to breakthroughs here.
This Special Issue aims to highlight translational research, lab-based research, and clinical insights that lead to improvements in the investigation, management, and monitoring of people who present with optic neuropathies.
Dr. Steffen Hamann
Dr. Susan Mollan
Guest Editors
Manuscript Submission Information
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Keywords
- compressive optic neuropathy
- inflammatory optic neuropathy
- ischemic optic neuropathy
- glaucoma
- hereditary optic neuropathy
- neuromyelitis optica spectrum disorder
- optic neuropathy
- optical coherence tomography imaging
- raised intracranial pressure
- traumatic optic neuropathy
