The Role of Fractalkine in Human Health and Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 193
Special Issue Editor
Interests: CX3CL1-CX3CR1 axis; inflammation; signal transduction; macrophages; microglia; neurodegenerative diseases; iron-related disorders; reproduction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Fractalkine, also known as CX3CL1, is the sole member of the CX3C chemokine subfamily with unique structural and functional properties. Unlike other chemokines, the polypeptide chain of human fractalkine is a 397-amino-acid protein containing a transmembrane domain. Fractalkine exists in a membrane-anchored form that facilitates intercellular interactions and a soluble form with potent chemoattractant activity. Fractalkine is the only known ligand for CX3CR1 regulating the MAPK, PI3 kinase, Akt/PKB, NFκB, or PLC signaling pathways, and thus cellular functions. Fractalkine plays a crucial role in the regulation of microglia; it is proposed to contribute to inflammatory brain disorders and neurodegenerative diseases. Fractalkine is involved in the pathogenesis of various clinical disease states, such as atherosclerosis, rheumatoid arthritis, multiple sclerosis, pancreatitis, diabetes, cancerous diseases, HIV infection, endometriosis, and pathological pregnancies. Fractalkine may be a potent diagnostic factor or biomarker in many diseases.
Particular attention will be devoted to papers describing new biochemical, molecular, physiological, pathological, or pharmacological aspects related to fractalkine and its receptor in health and diseases. Clinical studies on fractalkine as a new potential diagnostic factor are also welcome to be submitted to this Special Issue.
Dr. Edina Pandur
Guest Editor
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Keywords
- fractalkine
- biomarker
- cell signaling
- inflammation
- immune cells
- inflammatory diseases neurodegeneration
- cancer
- diabetes
