Advances in Protein Tyrosine Phosphatases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 15 July 2024 | Viewed by 91
Special Issue Editor
Interests: protein tyrosine phosphatases; AlphaFold; structure-based drug design; biotherapeutics; platelets; thrombosis; diabetes; obesity; AI; phosphatases inhibitors; CD148; protein-protein interactions
Special Issue Information
Dear Colleagues,
Protein tyrosine phosphatases (PTPs) are signalling molecules that play critical roles in cellular regulation underlying diverse physiological events. Aberrant signalling of these enzymes as a result of genetic mutation or altered expression levels has been associated with several diseases, specifically cancer. Many PTPs are regulated as drug targets, and several inhibitors have now entered clinical trials.
Protein tyrosine phosphorylation is a common post-translational modification that can create novel recognition motifs for protein interactions and cellular localization, affect protein stability, and regulate enzyme activity. PTPs are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins and thereby regulate these processes.
This Special Issue aspires to provide a platform for showcasing molecular mechanistic research on protein tyrosine phosphatases with a special focus on potential pharmacological applications. We warmly welcome your submissions of original papers and reviews based on the results of research from molecular viewpoints.
Dr. Alastair J. Barr
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- PTPs
- protein tyrosine phosphatases
- signalling molecules
- drug target
- genetic mutation
- post-translational modification
- pharmacological applications
- phosphate
- phosphorylation
