Molecular Therapies and Mechanisms of Gynecological Cancers
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 August 2024 | Viewed by 321
Special Issue Editor
Interests: ovarian cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Epigenetic changes represent mechanisms that can regulate cell fate in different mode of action. The affected cell can either undergo apoptosis or proliferation, depending on the epigenetic modulators affected. It is now widely believed that epigenetics is involved in the pathogenesis of many disorders, including gynaecological cancers, like ovarian cancer, endometrial cancer, breast cancer, vulvar cancer, cervical cancer, sarcomas. Early research into epigenetic disease in cancer focused on single gene methylation patterns.
However, newer genome-wide methods have identified a group of genes and enzymes whose regulation is epigenetically altered during the disease progression. DNA methyltransferases(DNMTs) and histone deacetylases (HDACs) are one of the key enzymes mediating epigenetic regulation of gene expression. Its improper function results in DNA hypermethylation and/or histone deacetylation in gene promoter regions that is associated with a reduction or silencing of transcription. DNMT and HDAC inhibitors induce DNA demethylation and histone acetylation, respectively, leading to reactivation of silenced genes and dramatic morphological and functional changes in cancer cells. The potential reversibility of epigenetic mechanisms makes them attractive candidates for the prevention and/or treatment. Detecting the epigenetic signature specific for particular gynaecological cancers could be useful in identifying potential biomarkers for disease detection, classification, monitoring, as well as could facilitate personalized treatment.
Dr. Maciej Skrzypczak
Guest Editor
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