Thioredoxin Reductase: Signaling Pathways and Pharmacological Targets
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 191
Special Issue Editor
Interests: redox regulation; redox medicine; redox biology; anticancer drugs; antioxidants; natural products
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Human thioredoxin reductase (TrxR) is a selenoprotein that utilizes highly reactive selenocysteine (Sec) residues in its active site. Of note, TrxR and thioredoxin (Trx) reduce many different target proteins that have been identified, including transcription factors, as well as signaling and structural proteins. Target proteins also include peroxidases, which in turn scavenge reactive oxygen species (ROS). Thus, TrxR and Trx play a central role in the maintenance of cellular redox homeostasis.
The pharmacological regulation of TrxR is typically presented in light of interactions with Sec residues and a few other mechanisms of action. The small-molecule-mediated regulation of TrxR signaling pathways has been investigated for its clinical significance and translational medicine in a variety of diseases. For example, the remarkable role of small molecules targeting the TrxR signaling pathway in anticancer and anti-infection, rheumatoid arthritis, and ischemia therapies has been explored in detail. Nonetheless, the rationale of the TrxR signaling pathway in therapeutic strategies for human diseases, the underlying molecular basis of small molecules targeting TrxR for therapeutic purposes, the downstream mechanisms of effect that may mediate therapeutic efficacy, and the diversity of therapeutic molecule structures and druggability are all topics that we will focus on in this Special Issue.
You may choose our Joint Special Issue in Antioxidants.
Prof. Dr. Junmin Zhang
Guest Editor
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Keywords
- thioredoxin reductase
- thioredoxin
- selenoprotein
- redox homeostasis
- peroxidases
- reactive oxygen species
- natural products
- redox regulation
- apoptosis
- signaling pathways
