Molecular Background of Posttraumatic Neurodegeneration: Previous Evidence and Future Research Directions
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 111
Special Issue Editor
2. Institute of Medical Science, University of Rzeszow, 35-959 Rzeszow, Poland
Interests: neurosurgery; neurotraumatology; neurodegeneration; traumatic brain injury; neurointensive care
Special Issue Information
Dear Colleagues,
Several theories have emerged in recent years that propose environmental risk factors as being causative for diverse neurogenerative diseases. Some of them were found using only epidemiologic coincidence, with the main discrimination factor being the possibility of proving the pathophysiological link between an external influence and the development of subsequent neurodegeneration. Here, a great number of molecular mechanisms were found and described for traumatic brain injury (TBI), leading to a loss of neuronal function and density. For this reason, the research field in the potential background of posttraumatic neurodegeneration is expanding.
This Special Issue will focus on the effects of single or repetitive brain trauma on the biomolecular processes, potentially leading to full-blown neurodegenerative disease. By causing a prolonged neuroinflammatory response, promoting oxidative stress, or directly damaging the fragile structures of the cytoskeleton in neural tissue components, TBI is believed to trigger and sustain the process of neurodegeneration in a variety of conditions. These include (but are not limited to) Alzheimer’s disease, Parkinsons’s disease and chronic traumatic encephalopathy.
This Special Issue intends to be an important body of evidence, summarizing the recent progress in the field. Overall, we aim to establish the most important interconnections between the molecular background of both TBI and neurodegenerative conditions and to track the innovative paths of research worth pursuing in future projects. All papers describing or summarizing recent progress in the area of research into molecular background in posttraumatic neurodegeneration are welcome.
Dr. Jacek Szczygielski
Guest Editor
Manuscript Submission Information
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Keywords
- traumatic brain injury (TBI)
- posttraumatic neurodegeneration
- axonal injury
- neuronal loss
- Alzheimer’s disease
- chronic posttraumatic encephalopathy
- tauopathy
- posttraumatic dementia
