Advances in Riboswitch Inhibitors
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 August 2024 | Viewed by 110
Special Issue Editor
Interests: protein synthesis inhibitors; antibiotic resistance; novel antibiotics; riboswitch inhibitors; RNA inhibitors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Riboswitches are important regulators of bacterial metabolism and control the transcription or translation of essential genes through elaborate structures of their 5′UTR. Due to their dynamic characteristics and pivotal regulatory function within bacterial metabolism, riboswitches have become a focal point for developing advanced RNA-targeting antibacterials to tackle drug resistance issues. In recent years, exploring various riboswitch structures across a spectrum of bacterial strains, including prominent human pathogens, has underscored their suitability as targets for novel compounds capable of disrupting their structure and function, with a decreased likelihood of resistance emerging. Particularly noteworthy is the effectiveness of mainstream antibiotics, which target the ribosome, in modulating the regulatory behavior and potential of numerous riboswitches, both in laboratory settings and within living organisms, highlighting the necessity for the further comprehensive investigation and biological assessment of new antibiotic candidates.
Prof. Dr. Constantinos Stathopoulos
Guest Editor
Manuscript Submission Information
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Keywords
- riboswitch
- noncoding RNA
- antibiotics
- resistance
- bacteria
- antimicrobial resistance
