The Role of Inflammasomes in Human Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 April 2024 | Viewed by 276
Special Issue Editor
Special Issue Information
Dear Colleagues,
The inflammasomes are innate immune system receptors/sensors that regulate the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules derived from host proteins. Extensive studies have demonstrated that inflammasomes play a vital role in aging, as well as infectious and autoimmune diseases, including type 2 diabetes, Alzheimer's disease, and atherosclerosis.
By releasing pro-inflammatory cytokines, inflammasomes contribute to the initiation and maintenance of local or systemic inflammation. This inflammatory milieu has been shown to have a role in dampening anti-tumor immunity and suppressing tumor development. However, inflammasomes have also been linked to cell proliferation, alterations in transcriptional activity, stimulation of angiogenesis, and ultimately to the promotion of tumor cell survival and metastasis. Our intention is to provide a friendly and open forum for sharing high-quality manuscripts that address every possible aspect of this complex dual role of the inflammasome activity. Full research papers, impactful communications, comprehensive systematic reviews, or featured opinions are particularly welcome. The main Special Issue topics are as follows:
- The role of the inflammasome in resistance to influenza virus infection;
- The role of inflammasomes in cancer pathogenesis;
- Activation and regulatory mechanism of the inflammasome in chronic inflammatory diseases;
- Molecular mechanisms of novel therapeutic approaches for cancer treatment targeting inflammasomes.
Dr. Marisol Fernández-Ortiz
Guest Editor
Manuscript Submission Information
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Keywords
- inflammasome
- IL-1 cytokines
- inflammatory caspases
- inflammasome activity manipulation
