The Role of Autophagy Processes in Neurodegenerative Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 259
Special Issue Editor
Special Issue Information
Dear Colleagues,
A hallmark event in neurodegenerative diseases (NDs) is the accumulation of misfolded proteins. The disease-associated proteins undergo misfolding from their native states to form neurofibrillary tangles that cause cellular toxicity and loss of neuronal connectivity. Emerging evidence suggests that autophagy, evolutionary conserved intracellular degradation machinery, contributes to the removal of aggregate-prone proteins in neurons, to support cellular homeostasis and protect against neurodegeneration. Defects in autophagy are often associated with the pathogenesis of NDs, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS). Thus, modulating autophagy is becoming a promising therapeutic approach against neurodegenerative disorders.
This Special Issue focuses on the molecular mechanisms of autophagy in the context of neurodegenerative disorders. We welcome submissions of original papers and reviews that cover this widely discussed topic.
Dr. Azra Fatima
Guest Editor
Manuscript Submission Information
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Keywords
- neurodegenerative diseases
- aggregate-prone proteins
- autophagy
- mitophagy
- autophagosome
- lysosome
