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Natural Products: New Insights into Overcoming Oxidative Stress in Pathological Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 676

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Guest Editor
Laboratory of Cellular Biology and Neurobiology, Department of Biology and Biotecnology, University of Pavia, 9-27100 Pavia, Italy
Interests: cell death; brain tumors; cisplatin; new platinum compounds; microscopy; immunohistochemistry; cell cultures
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Special Issue Information

Dear Colleagues,

The concept of oxidative stress as “a disturbance in the pro-oxidant–antioxidant balance in favor of the former” was introduced about 40 years ago, and, in the last ten years alone, about 200,000 articles studying the link between oxidative stress and the acute/chronic phase of several diseases (from metabolic and chronic disorders to cancers) have been published at PubMed.

The oxidative stress process is activated following an imbalance between the production of reactive oxygen species (ROS) and their accumulation in cells and tissues. Although ROS play a key role in both the maintenance of cellular homeostasis and the regulation of cell activity, they can significantly increase in the presence of specific environmental factors, e.g., pollutants, ionizing radiation, or antiblastic drugs.

ROS are mainly produced by the mitochondria, both in physiological and pathological conditions, but these organelles are unable to prevent ROS overproduction.

In the literature, it has been reported that oxidative stress can be responsible for the development of metabolic diseases, chronic/degenerative diseases, and tumors. Furthermore, it can be associated with the onset of autoimmune diseases, the acceleration of the organic aging process, and acute pathologies.

How can we avoid damage related to oxidative stress? Cells are able to produce a variety of antioxidant enzymes that may break down radical chain reactions. However, these ROS scavengers are not always sufficient to fight oxidative stress. A high level of antioxidants can be recovered through the diet, e.g., by the use of nutraceuticals. A regulated consumption of nutraceuticals can help in maintaining a stable redox state, preventing oxidative stress.

This Special Issue of International Journal of Molecular Sciences on “Natural Products: New Insights into Overcoming Oxidative Stress in Pathological Diseases”, supervised by Dr. Maria Grazia Bottone (University of Pavia, Italy) and supported by Dr. Fabrizio De Luca (University of Pavia, Italy). In this Special Issue, we invite you to contribute original research articles reporting data from both experimental and clinical studies, as well as review articles, that allow a better understanding of the effects of nutraceuticals, dietary supplements, and functional foods on different diseases showing the direct involvement of the oxidative stress pathway.

Dr. Maria G. Bottone
Guest Editor

Manuscript Submission Information

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Keywords

  • natural products
  • nutraceuticals
  • oxidative stress
  • antioxidants
  • ROS
  • redox signaling
  • oxidative stress
  • pathological diseases

Published Papers (1 paper)

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Research

33 pages, 47187 KiB  
Article
A Phyto-mycotherapeutic Supplement, Namely Ganostile, as Effective Adjuvant in Brain Cancer Management: An In Vitro Study Using U251 Human Glioblastoma Cell Line
by Ludovica Gaiaschi, Fabrizio De Luca, Elisa Roda, Beatrice Ferrari, Claudio Casali, Chiara Rita Inguscio, Federica Gola, Enrico Pelloni, Elena Savino, Mauro Ravera, Paola Rossi and Maria Grazia Bottone
Int. J. Mol. Sci. 2024, 25(11), 6204; https://doi.org/10.3390/ijms25116204 - 5 Jun 2024
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Abstract
The current standard oncotherapy for glioblastoma is limited by several adverse side effects, leading to a short-term patient survival rate paralleled by a worsening quality of life (QoL). Recently, Complementary and Integrative Medicine’s (CIM) innovative approaches have shown positive impacts in terms of [...] Read more.
The current standard oncotherapy for glioblastoma is limited by several adverse side effects, leading to a short-term patient survival rate paralleled by a worsening quality of life (QoL). Recently, Complementary and Integrative Medicine’s (CIM) innovative approaches have shown positive impacts in terms of better response to treatment, side effect reduction, and QoL improvement. In particular, promising potential in cancer therapy has been found in compounds coming from phyto- and mycotherapy. The objective of this study was to demonstrate the beneficial effects of a new phyto-mycotherapy supplement, named Ganostile, in the human glioblastoma cell line U251, in combination with chemotherapeutic agents, i.e., Cisplatin and a new platinum-based prodrug. Choosing a supplement dosage that mimicked oral supplementation in humans (about 1 g/day), through in vitro assays, microscopy, and cytometric analysis, it has emerged that the cells, after 48hr continuous exposure to Ganostile in combination with the chemical compounds, showed a higher mortality and a lower proliferation rate than the samples subjected to the different treatments administered individually. In conclusion, our data support the use of Ganostile in integrative oncology protocols as a promising adjuvant able to amplify conventional and new drug effects and also reducing resistance mechanisms often observed in brain tumors. Full article
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