Natural Products: New Insights into Overcoming Oxidative Stress in Pathological Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: 31 August 2024 | Viewed by 110
Special Issue Editor
Interests: cell death; brain tumors; cisplatin; new platinum compounds; microscopy; immunohistochemistry; cell cultures
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The concept of oxidative stress as “a disturbance in the pro-oxidant–antioxidant balance in favor of the former” was introduced about 40 years ago, and, in the last ten years alone, about 200,000 articles studying the link between oxidative stress and the acute/chronic phase of several diseases (from metabolic and chronic disorders to cancers) have been published at PubMed.
The oxidative stress process is activated following an imbalance between the production of reactive oxygen species (ROS) and their accumulation in cells and tissues. Although ROS play a key role in both the maintenance of cellular homeostasis and the regulation of cell activity, they can significantly increase in the presence of specific environmental factors, e.g., pollutants, ionizing radiation, or antiblastic drugs.
ROS are mainly produced by the mitochondria, both in physiological and pathological conditions, but these organelles are unable to prevent ROS overproduction.
In the literature, it has been reported that oxidative stress can be responsible for the development of metabolic diseases, chronic/degenerative diseases, and tumors. Furthermore, it can be associated with the onset of autoimmune diseases, the acceleration of the organic aging process, and acute pathologies.
How can we avoid damage related to oxidative stress? Cells are able to produce a variety of antioxidant enzymes that may break down radical chain reactions. However, these ROS scavengers are not always sufficient to fight oxidative stress. A high level of antioxidants can be recovered through the diet, e.g., by the use of nutraceuticals. A regulated consumption of nutraceuticals can help in maintaining a stable redox state, preventing oxidative stress.
This Special Issue of International Journal of Molecular Sciences on “Natural Products: New Insights into Overcoming Oxidative Stress in Pathological Diseases”, supervised by Dr. Maria Grazia Bottone (University of Pavia, Italy) and supported by Dr. Fabrizio De Luca (University of Pavia, Italy). In this Special Issue, we invite you to contribute original research articles reporting data from both experimental and clinical studies, as well as review articles, that allow a better understanding of the effects of nutraceuticals, dietary supplements, and functional foods on different diseases showing the direct involvement of the oxidative stress pathway.
Dr. Maria G. Bottone
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- natural products
- nutraceuticals
- oxidative stress
- antioxidants
- ROS
- redox signaling
- oxidative stress
- pathological diseases
