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Non-coding RNAs in the Regulation of Transcription and Epigenetic Mechanisms in Complex Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 149

Special Issue Editor

1. CNR, Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”, Via Pietro Castellino 111, 80131 Naples, Italy
2. Department of Science and Technology, University of Naples “Parthenope", Centro Direzionale, Isola C4, 80143, Naples, Italy
Interests: human genetic diseases; molecular mechanism pathogenesis; whole-transcriptome analysis; non-coding RNAs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Non-coding RNAs (ncRNAs) are gaining increasing attention both as possible therapeutic targets and as diagnostic biomarkers and specific predictors. This has facilitated investigations into what concerns their applicability since most of the genetic variations associated with diabetes are found in regions of the human genome that do not code for proteins. In fact, the human genome can be extensively transcribed into many ncRNAs, and they are closely linked to the onset and development of diseases.

The increase in non-protein-coding transcripts in complex organisms has led to the hypothesis that ncRNAs represent the components of a regulatory system parallel to that mediated by proteins but much more sophisticated. The mechanisms underlying the regulation of ncRNA gene expression have not been fully explained and, in fact, involve mechanisms that regulate transcription at the epigenetic level for mRNA processing and the control of protein activity.

It should be noted that advancing our understanding of ncRNAs and the mechanisms involved in transcriptional circuits could lead to new insights into the pathogenic mechanisms of complex diseases. Therefore, this Special Issue will focus on presenting molecular genetics and genomics studies that explore the effects of ncRNAs on transcriptional regulation and epigenetic mechanisms.

Dr. Mariagiovanna Tramontano from the University of Campania “Luigi Vanvitelli” will assist in managing the special issue.

Prof. Dr. Alfredo Ciccodicola
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • non-coding RNAs
  • regulation of transcription
  • epigenetic mechanisms
  • complex diseases

Published Papers

This special issue is now open for submission.
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