Tau Pathobiology in Neurodegenerative Diseases: From Molecular Mechanisms to Therapeutic Advances
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 15 July 2024 | Viewed by 193
Special Issue Editors
Interests: tau protein; tau cleavage; amyloid beta; Alzheimer's disease, neurodegeneration; retina; eye degeneration; synaptotoxicity; immunotherapy; Nerve Growth Factor (NGF)
Special Issues, Collections and Topics in MDPI journals
2. Institute of Translational Pharmacology (IFT), National Research Council (CNR), Via Fosso del Cavaliere 100, 00133 Rome, Italy
Interests: tau protein; Alzheimer's disease (AD); amyloid beta; Amyloid Precursor Protein (APP); synapse; non-AD tauopathies; immunotherapy; neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Alzheimer’s Disease (AD) and other human tauopathies, a family of neurodegenerative disorders characterized by cognitive and non-cognitive symptoms and with broad differences in neuropathological signs and clinical manifestations, see alterations in the metabolism of tau protein via accumulation in aggregates. The phenotypic heterogeneity of tauopathies represents a challenge in understanding the key pathophysiological mechanisms and in developing diagnostic and therapeutic strategies to slow down disease progression. In order to advance our understanding of tau’s pathogenic role, this Special Issue of the International Journal of Molecular Sciences (IJMS) in the Molecular Neurobiology section is dedicated to publishing research and review articles that provide important findings related to tau-mediated molecular mechanisms of neuronal toxicity and innovative therapies to address these issues.
Dr. Valentina Latina
Dr. Giuseppina Amadoro
Guest Editors
Manuscript Submission Information
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Keywords
- Alzheimer’s disease
- tauopathies
- tau neurotoxicity
- cellular and animal models
- signaling pathways
- tau-targeting therapies
