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Bioactive Compounds in Cancer, Inflammation and Related Diseases 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 July 2024 | Viewed by 550

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Special Issue Information

Dear Colleagues,

Inflammation is critically involved in host defenses against infectious agents and injury, but it also helps reduce damage to the body in many diseases, from viral infections and cancer to acute and chronic injury. Therefore, the discovery of inflammation-related biomarkers is the goal of many studies focused on the pathogenesis, diagnosis, prognosis and treatment of inflammation-related comorbidities. This Special Issue aims to publish research papers and reviews concerning biomarkers of inflammation-related diseases, with a focus on the occurrence and progress of Chinese herbal medicines, foods and active ingredients in pathological conditions such as cancer, immune diseases, viral infections, cardiovascular-related diseases, etc. The molecular mechanisms underlying metabolic diseases and all other pathological states associated with inflammation are also of interest. In addition, an association with inflammation has also been found in infectious diseases such as COVID-19. This knowledge should facilitate the development of strategies to predict disease susceptibility, target and monitor treatments and ultimately develop new approaches to prevent and treat diseases associated with inflammatory states.

Prof. Dr. Guan-Jhong Huang
Guest Editor

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  • oxidative disorders
  • inflammatory disorders
  • molecular signaling
  • bioactive compounds
  • cytokine

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13 pages, 4921 KiB  
Anti-SARS-CoV-2 Viral Activity of Sweet Potato Trypsin Inhibitor via Downregulation of TMPRSS2 Activity and ACE2 Expression In Vitro and In Vivo
by Wen-Ping Jiang, Jeng-Shyan Deng, Chia-Chen Yu, Jaung-Geng Lin and Guan-Jhong Huang
Int. J. Mol. Sci. 2024, 25(11), 6067; https://doi.org/10.3390/ijms25116067 - 31 May 2024
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Known as COVID-19, it has affected billions of people worldwide, claiming millions of lives and posing a continuing threat to humanity. This is considered one of the most extensive pandemics ever [...] Read more.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Known as COVID-19, it has affected billions of people worldwide, claiming millions of lives and posing a continuing threat to humanity. This is considered one of the most extensive pandemics ever recorded in human history, causing significant losses to both life and economies globally. However, the available evidence is currently insufficient to establish the effectiveness and safety of antiviral drugs or vaccines. The entry of the virus into host cells involves binding to angiotensin-converting enzyme 2 (ACE2), a cell surface receptor, via its spike protein. Meanwhile, transmembrane protease serine 2 (TMPRSS2), a host surface protease, cleaves and activates the virus’s S protein, thus promoting viral infection. Plant protease inhibitors play a crucial role in protecting plants against insects and/or microorganisms. The major storage proteins in sweet potato roots include sweet potato trypsin inhibitor (SWTI), which accounts for approximately 60% of the total water-soluble protein and has been found to possess a variety of health-promoting properties, including antioxidant, anti-inflammatory, ACE-inhibitory, and anticancer functions. Our study found that SWTI caused a significant reduction in the expression of the ACE2 and TMPRSS2 proteins, without any adverse effects on cells. Therefore, our findings suggest that the ACE2 and TMPRSS2 axis can be targeted via SWTI to potentially inhibit SARS-CoV-2 infection. Full article
(This article belongs to the Special Issue Bioactive Compounds in Cancer, Inflammation and Related Diseases 2.0)
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