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Three-Dimensional Bioprinting and Gene Therapy in Osteoarthritis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 215

Special Issue Editor

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Guest Editor
Department of Orthopaedic Surgery, Homer Stryker M.D. School of Medicine, Western Michigan University, Kalamazoo, MI 49024, USA
Interests: 3D bioprinting; RNA-based gene therapy; cartilage regeneration; osteoarthritis
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Special Issue Information

Dear Colleagues,

Osteoarthritis (OA) is a major degenerative joint disease due to the progressive degradation of the articular cartilage, inflammation of the synovium and osteophyte formation. OA is associated with joint pain, instability and disability. Aging and obesity are major risk factors of OA; however, other factors such as chronic inflammation, knee injuries and genetic predisposition have also been reported to have a significant impact in the initiation and progression of OA. Unfortunately, actual available OA treatments aim to manage pain, decrease inflammation and improve mobility. Gene delivery strategies have demonstrated promising alternative therapeutics for inhibiting inflammation and cartilage degeneration and for enhancing cartilage growth and healing. Three-dimensional bioprinting in combination with gene therapy enables the ex vivo fabrication of implantable cartilage constructs that overexpress the therapeutic genes necessary to establish joint homeostasis.

The objective of this Special Issue is to address the recent progress made in engineered viral, non-viral and RNA-mediated gene delivery systems used for OA treatment. Advances in 3D bioprinting and bioink engineering for cartilage regeneration will also be discussed. Submissions, including original papers and reviews, focusing on molecular studies in biology and chemistry with a strong emphasis on molecular biology and molecular medicine are welcome.

Dr. Akkouch Adil
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • osteoarthritis
  • gene therapy
  • bioink formulations
  • 3D bioprinting
  • gene delivery

Published Papers

This special issue is now open for submission.
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