NRF2/KEAP1 Signalling in Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 June 2024 | Viewed by 96
Special Issue Editor
Special Issue Information
Dear Colleagues,
We are pleased to invite you to submit a manuscript to the Special Issue “NRF2/KEAP1 Signalling in Cancer”. The nuclear factor erythroid 2-related factor 2 (NRF2)/Kelch-like ECH-associated protein 1 (KEAP1) is the most studied signaling pathway involved in cellular defense against oxidative stress, a process characterized by an imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses. Oxidative stress is considered a mechanism that increases susceptibility to developing age-related pathologies, including cancer. In addition, NRF2/KEAP1 signaling is involved in chemoresistance and radioresistance occurrence in several types of cancers significantly worsening the outcome of the disease.
Thus, it is necessary to develop new therapeutic approaches that can improve diagnosis and treatment outcomes. Therefore, we need a better understanding of the molecular changes occurring in cancer pathogenesis to develop new molecular biomarkers able to predict tumor behavior and the risk of disease recurrence and chemoresistance. Moreover, understanding the molecular mechanisms involved in NRF2/KEAP1 modulation can significantly improve the therapeutic strategies used in cancer treatment.
This Special Issue, therefore, welcomes original research articles and reviews related to the role of NRF2/KEAP1 signaling in cancer. Communications, mini-reviews, systematic reviews and meta-analyses are also welcome.
We look forward to receiving your contributions.
Dr. Sonia Fantone
Guest Editor
Manuscript Submission Information
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Keywords
- oxidative stress
- cancer
- aging
- senescence
- inflammation
- ovarian cancer
- prostate cancer
- antioxidants
