The Na, K-ATPase in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 197
Special Issue Editor
Special Issue Information
Dear Colleagues,
The Na+,K+-ATPase, known as the Na+-pump, has been studied intensively, for nearly 70 years. Nonetheless, it is still at the center of interest for various disciplines. The central role of the pump is related to the exchange of Na+ and K+, at the expense of the hydrolysis of ATP, an activity realized by the α subunit. Nevertheless, the accessory subunits, β and γ, play an important role in this function. Initially, the role of the three isoforms of the β subunit of animal Na+/K+-ATPases has been shown to support protein folding and stability and to serve a role in occluding bound K+. Both old and emerging information at the molecular level strongly suggest that at least two isoforms of the β-subunit function such as cell-adhesion molecules in epithelia (β1) and as an adhesion molecule on the plasma membrane of astrocytes (β2/AMOG). The γ subunit (FXYD2) belongs to the family of regulatory proteins known as FXYD proteins. In mammals, there are seven members of this family, which are characterized by their small size (66–178 amino acids) and contain the sequence signature FXYD (PFXYD in mammals). These auxiliary subunits have been demonstrated to modulate kinetic properties and enhance enzyme stability within the membrane, with effects that vary depending on the tissue and isoform. While the direct impact on substrate affinities or Vmax values for Na,K-ATPase activity is modest, FXYDs may serve to finely adjust ion transport within specific organs or tissues.
In this Special Issue, our aim is to publish research and review articles describing current knowledge and data on the structure–function relationship of the Na+-pump in health and diseases. We are looking for articles that explore the roles played by α, β, and γ subunits at the molecular, biochemical, physiological, pharmacological, and genetic levels and how they impact the development, normal structure and function, and pathology of different tissues and organisms.
The scope of the Special Issue includes, but is not limited to, the following topics:
- The structure of α, β, and γ subunits as components of the Na,K-ATPase.
- The role of the different subunits in modulating the ion transport of Na,K-ATPase.
- The adhesive properties of β-subunits in epithelia and nervous system.
- The role of α, β, and γ subunits in neuronal development.
- The role of α, β, and γ subunits of Na,K-ATPase with cancer.
- Disorders related to mutations in α-subunits of the Na,K-ATPase.
- Disorders related to β-subunits.
- Disorders related to FXYD proteins.
Dr. Liora Shoshani
Guest Editor
Manuscript Submission Information
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Keywords
- Na+,K+-ATPase
- α-subunit
- β-subunit
- γ subunits
- FXYD
