Notch Signaling Pathways
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 1462
Special Issue Editor
Special Issue Information
Dear Colleagues,
Notch signal transduction is an evolutionarily conserved pathway in multicellular organisms. It regulates cell fate decisions during development and maintains the balance of adult tissues. The Notch pathway mediates parallel cellular signaling, and through the ligand–receptor crosstalk, both signal-sending and -receiving cells are affected, thereby regulating a series of cell fate decisions in neuronal, cardiac, immune and endocrine development processes. The Notch pathway is also a key cancer driver and is important in tumor progression in certain cell types, while being tumor-prohibitive in others. Early research suggests that Notch activity is highly dependent on the expression of the intracellular cleaved domain of Notch-1 (NICD). However, recent insights into Notch signaling reveal the presence of Notch pathway signatures, which may vary depending on different cancer types and environments. Indeed, the Notch pathway has become exceedingly complex, with canonical and noncanonical Notch signaling and crosstalk with various key cellular signaling pathways. Due to its role in disease and cancer, Notch signaling is an attractive target for therapeutic intervention.
This Special Issue aims to attract contributions on all aspects of the role of the Notch signaling pathway in the tumor microenvironment, neuronal, cardiac, immune and endocrine development processes. Emphasis will be placed on new research articles related to Notch therapeutics in disease and cancer, and the regulation of Notch signaling in tumor development and progression.
Dr. Marcia Bellon
Guest Editor
Manuscript Submission Information
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Keywords
- Notch signaling
- Notch and the tumor microenvironment
- Notch therapeutics
- Notch neuronal aspects
- Notch cardiac aspects
- Notch immune aspects
- Notch endocrine development processes
- Notch and stem cells
- Notch single cell analysis
- Notch noncanonical signaling pathways
- Notch as a tumor suppressor
