Dopamine, Histamine, Serotonin—Receptors, Ligands and Their Biological Role in Central Nervous System Diseases, 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 194
Special Issue Editors
Interests: medicinal chemistry; multitarget ligands; drug design; synthesis; neurodegenerative disorders; histamine H3 receptors
Special Issues, Collections and Topics in MDPI journals
Interests: neurodegeneration; CNS diseases; Alzheimer's disease; Parkinson's disease; novel treatments for CNS diseases; neuroprotective agents; dual targeting drugs; multi-targeting drugs; histamine; histamine receptors; biogenic amines
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The human brain, with its network of neurotransmitters, is still an intriguing mystery to us. Neurotransmitters direct the work of the entire brain, transmitting important information and influencing important vital functions.
Dopamine and serotonin are some of the most important neurotransmitters in our brain. The role of histamine is equally important in the sleep-wake cycle or in processes related to memory and concentration. Each of these amines, acting through their receptors, influences many important vital functions and plays an important role in the onset and course of many CNS diseases.
An in-depth knowledge and understanding of the mechanisms of these diseases onset and progression, especially those with an important role for dopamine, histamine or serotonin, can help identify early symptoms of them, and introduction of a proper therapy.
Papers on these amines, their receptors and ligands are encouraged. Particularly works involving the search for new active compounds, especially those with multitargeting activity, and their pharmacological or pharmacokinetic evaluation. All preclinical studies (including in vitro, ex vivo and in vivo studies) related to effects via dopamine, histamine or serotonin are welcome.
Dr. Dorota Łażewska
Dr. Anna Stasiak
Guest Editors
Manuscript Submission Information
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Keywords
- biogenic amines (histamine, dopamine, serotonin)
- receptors
- ligands
- antagonist/inverse agonist
- affinity
- intrinsic activity
- multitarget ligands
- molecular modeling
- CNS diseases
- neurodegeneration
- psychiatric disorders
- pain
- in vitro studies
- in silico studies
- in vivo studies
