TSPO in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 247
Special Issue Editors
Interests: TSPO; pharmacology; inflammation; cell death; cell proliferation
Special Issue Information
Dear Colleagues,
In the past few decades, the role of TSPO in human diseases has been elaborated upon. Numerous studies have demonstrated its involvement in cellular proliferation, cell death, steroidogenesis, inflammation, and cellular metabolism. These cellular functions appear to be relevant to human diseases, including cancer, neurodegeneration, endocrine dysfunctions, inflammatory diseases, and autoimmune diseases. Novel TSPO ligands, with variability in their selectivity and affinity to TSPO, have been synthesized. These ligands were used in experimental models of human diseases and in brain imaging to demonstrate brain gliosis as a marker for neurodegeneration or neuroinflammation. In the peripheral dimension it was found that some TSPO ligands suppress macrophage and microglia activation, indicating anti-inflammatory activity of these ligands.
Unfortunately, most of these studies are descriptive. There is an unmet need for the elucidation of the underlying mechanisms and pathways involved in the therapeutic effects of TSPO ligands. Furthermore, it is currently unclear as to whether the putative therapeutic effects are relevant to preventive treatments or to the management of already-pathological conditions.
Translational TSPO research is needed to discover new treatments for relevant human pathologies. The main feature of this Special Issue is the provision of open source sharing of significant studies in the field of TSPO that may advance the understanding of the role of TSPO in pathological conditions and the discovery of novel diagnostic technologies as well as TSPO-targeted therapeutics.
Topics in this Special Issue include, but are not limited to, the following:
- Key biological processes, such as cell cycle, DNA repair, apoptosis, autophagy, endocrinology, cellular death, cellular or tissue repair, and signaling pathways.
- Molecular brain and peripheral pathologies.
- TSPO in cancer.
- TSPO ligands in the treatment of cancer, inflammation, neurodegeneration, and endocrine diseases.
- Translational TSPO research.
- TSPO ligands for the diagnosis of brain and peripheral diseases
- High-throughput technologies: genomics, proteomics, metabolomics, microarray, next-generation sequencing, and other omics technologies in TSPO research.
- Genomic and proteomic TSPO-related databases as well as applications.
Prof. Dr. Moshe Gavish
Prof. Dr. Abraham Weizman
Guest Editors
Manuscript Submission Information
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Keywords
- cancer
- mitochondria
- steroidogenesis
- apoptosis
- inflammation
- cell cycle
- cell death
