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Immune Modulation of Macrophages 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 163

Special Issue Editors

1. Faculty of Medicine, Macau University of Science and Technology, Macau SAR, China
2. Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
Interests: genetics and development biology of birth defects; genomics of childhood tumors; immunology and inflammation
Special Issues, Collections and Topics in MDPI journals
Dr. Yan Chen
E-Mail Website
Guest Editor
1. Faculty of Medicine, Macau University of Science and Technology, Macau SAR, China
2. Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
Interests: immunology and inflammation in birth defects and tumors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

A macrophage is a multifunctional cell type presenting consistent phenotype changes over its lifespan beginning from the embryonic period. The differentiation and maturation dependent on the microenvironment and in response to the internal and external stimuli often result in the heterogenicity of the cells, by which the interpretation of the function becomes difficult. As a result, therapeutic treatment in cell targeting has frequently been ineffective. With the increased knowledge provided by updated forms of technology, especially multi-omics and spatial transcriptomic technologies, the functional understanding of macrophages in both physiological and pathological conditions in different tissues and organs is becoming increasingly advanced. In line with the creation of new technologies, the modulation of the cells in different pathological conditions, such as cancer, in response to the different drugs or reagents for different diseases during the development stages will provide a novel phenotypical assessment. A good understanding of the alternating functions of macrophages will help scientists to develop new strategies in terms of precision or personalized therapies in treating diseases.

This Special Issue entitled “Immune Modulation of Macrophages 2.0” invites submissions of original reviews in this field of research, and focuses on the advanced technology concerning the understanding of the heterogenicity of cells in the disease process, especially in the phenotype changes and pathway analysis in response to the external treatment in disease treatments.

Prof. Dr. Paul Kwong Hang Tam
Dr. Yan Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • macrophages
  • treatment
  • phenotype change
  • pathway analysis

Published Papers

This special issue is now open for submission.
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