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Structure-Function Studies on Human Aromatase and Role in Pathologies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 271

Special Issue Editors


E-Mail Website
Guest Editor
Department of Life Sciences and Systems Biology, University of Torino, 10123 Torino, Italy
Interests: aromatase; cytochromes P450; steroid hormones; endocrine disrupting chemicals
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Pediatric Endocrinology Diabetology and Metabolism, University Children’s Hospital, Inselspital, 3010 Bern, Switzerland
2. Translational Hormone Research Program, Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland
Interests: cytochromes P450; steroid metabolism; aromatase; hormone dependent cancers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Aromatase (CYP19A1), a cytochrome P450 enzyme responsible for the conversion of androgens to estrogens, is a key player in the endocrine system. As understanding the complex role of aromatase in various pathologies is crucial for the development of targeted therapies, research is ongoing to unravel the complex interplay between aromatase, estrogen and different pathologies.

Moreover, it is important to introduce new players into this picture, the so-called endocrine-disrupting chemicals (EDCs), exogenous substances interfering with the functioning of the endocrine system. Some EDCs can affect aromatase activity, leading to disturbances in hormonal balance and potentially causing a range of adverse health effects. 

The aim of this special issue is to collect original papers and reviews that add new knowledge to the following potential topics:

  • Structural and functional studies on aromatase
  • Regulation of aromatase expression and activity by redox partners, regulatory proteins and post-translational modifications
  • Role of aromatase in hormone-dependent pathologies
  • Impact of EDCs on aromatase expression and activity
  • Aromatase as a drug target and novel chemical leads for its inhibition.

Dr. Giovanna Di Nardo
Prof. Dr. Amit V. Pandey
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aromatase
  • CYP19A1
  • endocrine system
  • estrogens
  • endocrine disrupting chemicals
  • polymorphism
  • redox partner interaction

Published Papers

There is no accepted submissions to this special issue at this moment.
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