Glioblastoma: From Molecular Mechanisms to Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 34
Special Issue Editor
Special Issue Information
Dear Colleagues,
Glioblastoma multiforme (GBM) is a lethal malignant adult brain cancer, known to recur following conventional therapy (surgical resection, chemotherapy, radiotherapy). While GBM is classified based on the transcriptional status of cells, recent studies using single cell and spatial omics have identified inter- and intra-tumoral heterogeneity in GBM, suggesting a need for novel and personalized treatment options. The “cold” immunosuppressive microenvironment, coupled with the tight surveillance of the blood–brain barrier in GBM results in dismal outcomes of immunotherapy clinically. Cellular communication between glioma cells and its microenvironment (including immune cells, endothelial cells, pericytes, astrocytes, neurons, and others) occur via the exchange of signals in a contact-dependent or -independent fashion, triggering therapeutic resistance and other alterations in the recipient cell. The former uses contact-dependent signaling pathways or the formation of nanotubes, while the latter employs the uptake of soluble factors or molecules encased in nanosized particles called extracellular vesicles (EVs) from donor cells. EVs are also being investigated to identify unique biomarkers in a liquid biopsy platform in order to determine the GBM subtype and evolution post treatment. Therefore, intercellular communication in conjunction with recent implications due to microenvironmental reorganization stimulates explorations of novel therapeutic strategies beyond conventional treatments.
This Special Issue, entitled “Glioblastoma: From Molecular Mechanisms to Therapies”, invites contributions, including original research articles, reviews, multi-omic analysis, or short perspective articles, on all aspects relating to the complex molecular pathophysiology of GBM, including diagnostic and prognostic biomarkers and novel therapeutic approaches to treat GBM.
Dr. Lata Adnani
Guest Editor
Manuscript Submission Information
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Keywords
- glioblastoma
- heterogeneity
- tumor microenvironment
- therapy resistance
- immunotherapy
- extracellular vesicles
- biomarkers
- vascular endothelial cells
- pericytes
- blood–brain barrier
