Epigenetic Biomarkers—Technologies and Applications in Complex Disease Diagnostics and Beyond
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 192
Special Issue Editor
Interests: DNA methylation; microRNAs; multi-omics biomarkers; liquid biopsy (blood, saliva, and CSF); extracellular vesicles; microarrays; next-generation sequencing; biomarkers for cancer-, cardiovascular-, and immune-mediated disease diagnostics
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Special Issue Information
Dear Colleagues,
The three main epigenetic mechanisms in mammalian cells are histone modification, DNA methylation, and non-coding RNA, and each mechanism works in a different way to regulate gene expression. Among epigenetic factors, DNA methylation is the longest known and best studied, as it plays an important role in imprinting and the developmental control of gene expression. Nevertheless, most importantly, the changes in DNA methylation patterns and microRNA profiles have been associated with health, aging, and many diseases. As DNA methylation and miRNA marks often represent an early event in the pathological process and are fairly stable and detectable in biological fluids, they are excellent biomarkers for liquid biopsy disease diagnosis. The availability of genome-wide technologies for DNA methylation and microRNA profiling, which are becoming more and more sensitive, has revolutionized the field of epigenetics and led to the discovery of a number of epigenetic biomarkers used in complex disease detection, as well as the prognosis, monitoring, and prediction of therapeutic responses.
In this Special Issue, we will discuss epigenetic biomarkers. The scope of this study ranges from the most basic to the most clinically applied mechanisms, incorporating methodologies, applications, and implications.
We request the submission of research articles or reviews on the following topics: DNA methylation, non-coding RNA, microRNA, liquid biopsy, extracellular vesicles, and technologies for epigenomics. In line with the journal’s mission—IJMS is a journal of molecular science—pure clinical studies are not suitable, but clinical submissions with biomolecular experiments are welcome.
Dr. Christa Nöhammer
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- epigenetics
- DNA/RNA methylation
- microRNAs
- biomarkers
- molecular technologies
- tissue
- biological fluids
