Chronic Liver Disease: Latest Research in Pathogenesis, Detection and Treatment 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 16 June 2024 | Viewed by 314
Special Issue Editors
Interests: liver cancer; liver fibrosis; NASH; liver signalling; liver models of disease; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Interests: liver disease; cancer research; liver fibrosis; metabolism and liver; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic liver diseases (CLDs) are a major challenge for global health. In patients with CLDs, liver cirrhosis and hepatocellular carcinoma (HCC) are the main contributors to morbidity and mortality, and remain a significant clinical problem. Chronic liver injuries are characterized by: 1) reiteration of liver injury and persisting inflammation as a major driving force for progressive fibrogenesis, resulting in increased deposition of extracellular matrix or ECM, eventually leading to cirrhosis and liver failure; 2) cellular levels that predominate the involvement of macrophages and Kupffer cells as well as highly proliferative, profibrogenic, migrating and contractile myofibroblast (MF)-like cells that may originate, following activation, from hepatic stellate cells (HSC/MFs). Several mechanisms can sustain fibrogenesis and its progression to advanced liver fibrosis, cirrhosis, liver failure and the development of HCC. Because of high incidence and mortality, there is a need to better understanding the mechanisms underlying the transition process from a healthy liver to end-stage disease in order to predict patients at a high risk of developing HCC, to detect HCC at an early stage and to predict evolution, recurrence and outcome after treatment.
In this Special Issue, I invite you to contribute original and cutting-edge research articles and reviews related to the title Chronic Liver Disease: Latest Research in Pathogenesis, Detection and Treatment 2.0.
More published papers could be found in the closed Special Issue: Chronic Liver Disease: Latest Research in Pathogenesis, Detection and Treatment.
Dr. Cristian Turato
Dr. Stefania Cannito
Guest Editors
Manuscript Submission Information
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Keywords
- NASH/NAFLD: pathogenesis, detection, and treatment
- hepatocellular carcinoma: pathogenesis, detection, and treatment
- inflammation in liver disease
- 3D liver models
- microbiota and liver disease
- mechanisms of damage and repair: ischemia-reperfusion injury
- cellular pathology in acute and chronic liver damage of different origin
- biomarkers in liver disease: emerging methods and potential applications
- immunology in the liver—from homeostasis to disease
