Understanding the Neurodegenerative Mechanisms Complexity for Successful Neuroprotective Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 364
Special Issue Editors
Interests: cellular models and intracellular mechanisms of neurodegeneration/neuroprotection; cell death pathways; glutamate receptors; synthetic or natural compounds with neuroprotective or anticancer activities; nanoparticles for CNS drug delivery
Interests: Parkinson’s disease; protein aggregation; animal models; fibril-induced alpha-synuclein aggregation; human iPCS-derived neurons; viral vectors for somatic transgenesis; neurotrophic factors; neuroinflammation; autophagy-lysosomal system; neurodegeneration
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Special Issue Information
Dear Colleagues,
The increased prevalence of neurodegenerative diseases with the aging population is nowadays a serious medical, societal, and economic problem since in clinics so far there is any successful neuroprotective drug to decrease these diseases burden. This is caused by not sufficient understanding of the complexity of various mechanisms and the mutual interplay between various cell death modes causing a selective degeneration of particular neuronal cell types in specific brain regions. Genetic predispositions, environmental factors, previous brain trauma episodes, coexisting metabolic diseases, viral or bacteria infections, among others, are thought to contribute to neurodegeneration. Excitotoxicity, increased oxidative stress, mitochondrial disruption, protein degradation systems dysfunctions, pathological protein aggregation, incorrect DNA damage response, and neuroinflammation could be listed as detrimental factors leading to neuronal loss. In recent years has been also highlighted the significant contribution of astrocytes and microglia dysfunctions to neurodegeneration. This special issue is aimed at updating the knowledge on the mechanisms of various neurodegenerative diseases. Based on a better understanding of the complexity and the mutual interplay between various pathological processes, new neuroprotective strategies or combined approaches could be proposed with the hope to achieve successful clinical neuroprotection. One of such mean could be targeted brain delivery of putative neuroprotective compounds which is intensively investigated in recent years.
Dr. Danuta Jantas
Dr. Andrii Domanskyi
Guest Editors
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Keywords
- cell death programmes in neurodegeneration
- neuroinflammation
- oxidative stress
- mitochondrial dysfunctions
- DNA damage in neurodegeneration
- autophagy
- pathological protein aggregation
- neuroprotective compounds
- nanoparticles for neuroprotection
