Roles of EMT (Epithelial-to-Mesenchymal) in Cancer Progression
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 October 2024
Special Issue Editor
Interests: Oncoviruses; gene cooperation; drug discovery; drug delivery; cancer therapeutics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Epithelial–mesenchymal transition (EMT) is an embryonic genetic program adapted by cancer cells to achieve invasion and metastasis. It is now well-established that the EMT event is a crucial physiological process in the progression of metastatic cancer, leading to the majority of cancer-related deaths. During EMT, cells undergo a dramatic conversion where they lose their epithelial biomarkers and acquire fibroblast-specific proteins in order to increase cell motility. Research has shown that various receptor tyrosine kinases (RTKs), such as EGF-Rs, c-Met, IGF-1R, and non-RTK c-Src activations, can trigger EMT and facilitate cancer progression through the PI3k/Akt/mTOR and RAF/MEK/ERK1/2 pathways, as well as β-catenin. Previous studies have also indicated that leptin and its receptor can induce EMT, leading to cancer invasion and metastasis via the PI3k/Akt signaling pathway. Thus, targeting EMT genes and the associated molecular pathways could be key strategies in managing metastatic carcinomas. Additionally, exploring multiomics approaches including genomics, transcriptomics, proteomics, and metabolomics may play a significant role in identifying new targets against EMT and metastatic cancers.
This Special Issue aims to provide updated insights into the recent basic and translational aspects of EMT and its impact on cancer progression. The papers included will discuss the fundamental role of EMT in cancer metastasis, therapy, resistance, and the interactions between cancer and normal cells, with the goal of developing innovative approaches to combat cancer.
Dr. Amber Yasmeen will be the Special Issue assistant.
Prof. Dr. Ala-Eddin Al Moustafa
Guest Editor
Manuscript Submission Information
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Keywords
- • Epithelial–mesenchymal transition
- • Cell migration and invasion
- • Cancer progression and EMT
- • Targeting EMT and/or its molecular pathways
- • Multiomic analysis of EMT
