Natural Bioactive Compounds in the Molecular Mechanisms of Endothelial Dysfunction
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 August 2023) | Viewed by 355
Special Issue Editor
Interests: endothelial dysfunction; atherosclerosis; epigenetic; oxidative stress; inflammation; mitochondria; natural compounds; senescence; cardiovascular
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Having a functional endothelium and vasculature is essential for tissue health and function. Dysfunctional endothelial cells lose their ability to maintain homeostasis, leading to deleterious consequences for both the vessels and the organs they supply. Endothelial dysfunction represents a complex process occurring as a consequence as well as contributing to the pathogenesis of many chronic degenerative diseases, including atherosclerosis, hypertension and type II diabetes. The use of bioactive natural compounds of animal or vegetal origin to treat endothelial dysfunction is increasing worldwide, thanks to their limited side effects. Although many natural substances with antioxidant and anti-inflammatory activity have been discovered, the elucidation of their molecular mechanisms in endothelial dysfunction is crucial for the development of efficient therapies to improve endothelial function and vascular homeostasis in disease.
The objective of this Special Issue is to study, at a molecular level, the mechanisms of action of bioactive natural compounds to reduce pathological complications associated with endothelial dysfunction. This Special Issue invites the submission of original research articles, reviews and opinion articles presenting studies on the evaluation of efficacy of natural compounds and elucidation of their mechanisms of action in the molecular processes of endothelial homeostasis.
Prof. Dr. Nunzia D'Onofrio
Guest Editor
Manuscript Submission Information
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Keywords
- natural compounds
- endothelial dysfunction
- mechanism of action
- molecular target
- bioactivity
- chronic degenerative disease
- epigenomic
- miRNA
