Arrhythmias: Molecular Mechanisms and Therapeutic Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 31
Special Issue Editor
Interests: SGLT2 inhibitors; antioxidants; diabetes; cardiovascular diseases; sleep apnea; ion channel; gap junction; prognosis; biomarker; arrhythmia
Special Issue Information
Dear Colleagues,
Sleep-disordered breathing (SDB) is defined by alterations in respiratory patterns that occur during sleep. The SDB subtypes are obstructive sleep apnea (OSA), central sleep apnea (CSA) and CSA–Cheyne–Stokes breathing (CSB). SDB has a negative impact on cardiovascular and neuroendocrine functions, as well as the quality of life. Therefore, it is a significant issue in both clinical and public health contexts. OSA is a common condition that affects approximately 1 billion persons globally.
The physiological pressures associated with SDB lead to long-lasting biological repercussions. These effects ultimately cause changes in the cardiovascular system, increasing the likelihood of developing cardiac arrhythmias. Specific triggers that cause arrhythmias in individuals with SDB have been identified through clinical and experimental studies. Reducing the intensity of these triggers seems to improve the negative effects of SDB. While arrhythmias have a wide range of phenotypes and causes (automaticity, triggered activity and re-entry), they all have cellular electrophysiologic characteristics. These include anomalies in action potential generation, repolarization or conduction caused by a complex interaction of molecular biology, ion channels, connexin and their intracellular control, as well as electrophysiological remodeling. Therefore, it is crucial to enhance our understanding of the molecular and electrophysiological mechanisms behind cardiac arrhythmias in patients with SDB in order to develop an accurate diagnostic and effective treatment plan.
This Special Issue will provide readers with updated information on the involvement of inflammation, oxidative stress, autonomic nerve system dysfunction, electrophysiologic alternation, ion channel, connexin and metabolic dysregulation in the molecular mechanisms of cardiac arrhythmias, specifically atrial fibrillation, ventricular arrhythmia, sudden cardiac death and bradycardia. The content will cover the transition from laboratory research to clinical applications. The articles will concentrate on the existing knowledge, significant unresolved concerns and forthcoming research to establish an advanced therapy for cardiac arrhythmias due to SDB.
Dr. Yung-Lung Chen
Guest Editor
Manuscript Submission Information
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Keywords
- cardiac arrhythmias
- atrial fibrillation
- ventricular arrhythmia
- electrophysiologic alternation
- ion channel
- connexin
- autonomic nerve system dysfunction
- sleep-disordered breathing
- obstructive sleep apnea
