Flow Cytometry for Safety Assessment in Drug Discovery
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 208
Special Issue Editor
Interests: flow cytometry; cell biology; metabolism; biochemistry; immunology; stem cell biology; macrophage
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Drug discovery is a complex and expensive process characterized by long development times and high attrition rates. The discovery of new pharmaceutical molecules benefits from relevant toxicological information at the early stages of the preclinical process. Flow cytometry is a single-cell-based technology allowing the exhaustive and dynamic molecular phenotyping of cells, both in vitro and ex vivo. While flow cytometry has found its classical applications in clinical medicine, in recent years flow cytometry methods have been successfully involved in the safety assessment of new molecular entities in preclinical drug development. Multiparametric flow cytometry analysis is an excellent tool for examining both the on-target and off-target effects of drug candidates, thus providing data on their efficiency and safety as well as allowing the mapping of toxicity pathways. On the other hand, real-time cytometry is suitable for detecting short-term and reversible drug effects on molecular dynamics and provides a suitable system to predict both acute and chronic effects of chemical compounds and biological modulators. The technical improvements in high-throughput flow cytometry applications are also an added value for preclinical drug discovery stages, as they allow for the performance of large multiparametric screening campaigns based on miniaturized cell-based assays, thus providing a cost-efficient system for pharmaceutical development. In this Special Issue we expect to provide literature reviews, research papers, and guidelines relevant to the application of flow cytometry in preclinical drug discovery.
Prof. Dr. José-Enrique O’Connor
Guest Editor
Manuscript Submission Information
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Keywords
- preclinical
- toxicity pathways
- screening
- off-target effects
- new molecular entities
- fluorescence
- cell-based assays
