Hypothalamic Inflammation and Metabolic Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (30 December 2023) | Viewed by 214
Special Issue Editor
Interests: metabolism; obesity; appetite axis; endometrial environment
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
At present, obesity is a worldwide pandemic with alarming increases especially in countries under development. High-fat and high-glycaemic-index diets are associated with obesity, although animal studies have shown that they are also associated with hypothalamic inflammation and subsequent obesity. The influx of lipids and/or glucose into the hypothalamus can cause local inflammation with subsequent metabolic disorders such as obesity and/or type 2 diabetes. Human studies with MRI of the hypothalamus have also revealed that obese patients have hypothalamic inflammation.
Furthermore, the centres of appetite, the arcuate and paraventricular nucleus, are located in the area of the hypothalamus where inflammation occurs. This can cause appetite disorders leading to obesity and/or type 2 diabetes. In addition, hypothalamic inflammation can affect other hormonal local centres of the hypothalamus and the neurons of GnRH, thus causing hormonal disorders such as early pubarche or polycystic ovary syndrome.
All of the above constitute a new novel hypothesis and probably involve known or still unknown molecular mechanisms that remain to be described. Our Special Issue aims to expose and describe these molecular mechanisms involved in the pathogenesis of hypothalamic inflammation and its known metabolic and possible hormonal manifestations.
Dr. Georgios Valsamakis
Guest Editor
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