The Role of Hypoxia, Normoxia and Hyperoxia in Cancer Initiation and Propagation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 July 2024 | Viewed by 72
Special Issue Editor
Interests: targeted therapies; molecular diagnostics; tumor Immunity
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The role of the tumor microenvironment for cancer initiation and propagation cannot be overemphasized. Normoxia is a state with normal oxygen levels of 20–21% in tissues; however, normal organ tissue oxygen concentrations away from the lung are usually much lower, and the term physoxia with a 5% oxygen level reflects this discordance. Hypoxia favors glycolysis with its end products ultimately leading to a lowering of pH and the promotion of tumorigenesis. Furthermore, hypoxia increases an established tumor’s potential to become metastatic. In contrast, hyperoxia creates a tumor microenvironment that supports the body’s immune system defense against cancer; however, the associated inflammation can cause ‘protumor inflammation’ mediated by IL-1B and is associated with local tissue damage.
This Special Issue of IJMS, ‘The Role of Hypoxia, Normoxia and Hyperoxia in Cancer Initiation and Propagation’, led by Dr. Mary M. Salvatore, aims to engage the scientific community in a conversation about oxygen concentration and its effect on cancer.
Dr. Mary M. Salvatore
Guest Editor
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Keywords
- hypoxia
- normoxia
- hyperoxia
- cancer initiation
- cancer propagation
