Role of Protein Kinase CK2 in Molecular Biology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 December 2023) | Viewed by 253
Special Issue Editor
Interests: signaling and enzymatic regulation of protein kinases; cell proliferation and malignancy; cancer prognosis; functional proteomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
CK2 (casein kinase 2, CKII) is a serine threonine kinase, known to be essential for eukaryotic cell signaling for proliferation, survival and development. More than 300 proteins have been identified as CK2 substrates in the cells, elucidating diverse molecular functions of CK2 that depend on its defined cellular localization and biological time axis. Recently, functional genomic studies have demonstrated alterations in CK2 catalytic subunit alpha (CSNK2A1) in developmental disease, along with accumulated evidence concerning the overexpression of CK2 gene and/or protein levels in multiple types of human cancers. Based on these findings, drug discovery targeting this kinase has been piloted worldwide. In view of these current research efforts, this Special Issue focuses on original research articles and reviews, investigating the mechanisms underlying the function of protein kinase CK2 in the field of molecular biology, genomics, functional proteomics, epidemiology, pharmacology, protein structural biology, and cell biology. Trans-omics studies elucidating the function of CK2 are also welcome.
Dr. Miwako Kato Homma
Guest Editor
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