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Effect of Apolipoproteins on Infectious Diseases and Inflammatory Processes

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 June 2024 | Viewed by 348

Special Issue Editors

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Guest Editor
Laboratory of Tissue Healing, Ontogeny, and Nutrition, Department of Morphology and Institute of Biomedicine, School of Medicine, Federal University of Ceará, Fortaleza 60430-270, Brazil
Interests: nutrition; intestinal permeability and inflammation; intestinal immune response; intestinal barrier function; enteric infections
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Interests: obesity; inflammation; immunity; bioactive compounds; nutrition; apolipoproteins
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Apolipoproteins are a class of molecules related to cholesterol metabolism and its carriage in the blood. Apolipoproteins may function in various enzymatic processes and distinct receptor activation, leading to important cell downstream signaling pathways, including the ones involved in immunoinflammatory function. The disruption of normal metabolic pathways affected by defective apolipoproteins and LPS signaling may lead to systemic inflammation and increased risk for cardiovascular diseases. Apolipoproteins, such as apoA-I, apoE, and apoB100, in complex with plasma lipoproteins, may interact with LPS and other bacterial products, thus affecting their traffic to the liver during either acute or chronic intestinal bacterial infections and enteropathies, altering hepatic macrophage (Kupffer cell) activation, and causing various degrees of liver injury, such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). A better understanding of the role of apoproteins and LPS on the gut–liver and gut–brain axes, in the context of environmental and dietary conditions, and their association with genetics, epigenetics factors, and different “omics” approaches is key to pursuing pharmacological targets for novel therapeutic strategies. Unravelling novel molecular roadmaps, biomarkers, and mechanisms of action (modelling with in silico studies, artificial intelligence, intestinal organoids, mini-gut, novel mouse infection strategies, etc.) of LPS/lipoproteins/apolipoproteins during the pathophysiology of infectious diseases may support future clinical studies and breakthrough drug discovery. This Special Issue should focus on innovative approaches and insights to dissect the molecular roles of apolipoproteins on infectious diseases from different etiologies, intestinal immune mucosal barrier dysfunction and dysbiosis, and their inflammatory processes with potential strategies and interventions for their amelioration.

Dr. Reinaldo B. Oria
Prof. Dr. Jacqueline Isaura Alvarez-Leite
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • apolipoproteins
  • lipoproteins
  • intestinal microbiota
  • gut-liver axis
  • inflammation
  • cholesterol
  • toll-like receptors

Published Papers

This special issue is now open for submission.
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