Effect of Apolipoproteins on Infectious Diseases and Inflammatory Processes
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 20 June 2024 | Viewed by 264
Special Issue Editors
Interests: nutrition; intestinal permeability and inflammation; intestinal immune response; intestinal barrier function; enteric infections
Special Issues, Collections and Topics in MDPI journals
Interests: obesity; inflammation; immunity; bioactive compounds; nutrition; apolipoproteins
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Apolipoproteins are a class of molecules related to cholesterol metabolism and its carriage in the blood. Apolipoproteins may function in various enzymatic processes and distinct receptor activation, leading to important cell downstream signaling pathways, including the ones involved in immunoinflammatory function. The disruption of normal metabolic pathways affected by defective apolipoproteins and LPS signaling may lead to systemic inflammation and increased risk for cardiovascular diseases. Apolipoproteins, such as apoA-I, apoE, and apoB100, in complex with plasma lipoproteins, may interact with LPS and other bacterial products, thus affecting their traffic to the liver during either acute or chronic intestinal bacterial infections and enteropathies, altering hepatic macrophage (Kupffer cell) activation, and causing various degrees of liver injury, such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). A better understanding of the role of apoproteins and LPS on the gut–liver and gut–brain axes, in the context of environmental and dietary conditions, and their association with genetics, epigenetics factors, and different “omics” approaches is key to pursuing pharmacological targets for novel therapeutic strategies. Unravelling novel molecular roadmaps, biomarkers, and mechanisms of action (modelling with in silico studies, artificial intelligence, intestinal organoids, mini-gut, novel mouse infection strategies, etc.) of LPS/lipoproteins/apolipoproteins during the pathophysiology of infectious diseases may support future clinical studies and breakthrough drug discovery. This Special Issue should focus on innovative approaches and insights to dissect the molecular roles of apolipoproteins on infectious diseases from different etiologies, intestinal immune mucosal barrier dysfunction and dysbiosis, and their inflammatory processes with potential strategies and interventions for their amelioration.
Dr. Reinaldo B. Oria
Prof. Dr. Jacqueline Isaura Alvarez-Leite
Guest Editors
Manuscript Submission Information
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Keywords
- apolipoproteins
- lipoproteins
- intestinal microbiota
- gut-liver axis
- inflammation
- cholesterol
- toll-like receptors
