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Special Issue "Ion Channels of Nociception 3.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 September 2023 | Viewed by 360

Special Issue Editor

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, Neulaniementie 2, 70211 Kuopio, Finland
Interests: synaptic transmission; neuronal plasticity; neuron-glia interactions; neuronal networks; purinergic mechanisms; mechanosensitive ion channels; neurotransmitter receptors in health and disease; receptor desensitization; receptor trafficking; modelling of receptor kinetics; mitochondria; reactive oxygen species; molecular and cellular mechanisms of pain and analgesia; migraine; neuroprotection
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Special Issue Information

Dear Colleagues, 

Molecular mechanisms of pain - especially of neuropathic, migraine and cancer pain - remain largely unsolved. It is known that pain signals are typically initiated in the peripheral terminals of dorsal root or trigeminal ganglia neurons. These nerve terminals are equipped with specific receptors reacting to chemical or physical stimuli, as well as a range of specific voltage-gated ion channels contributing to generation and propagation of nociceptive spikes.

The molecular structures of many ion channels implicated in nociception are known, facilitating the development of new anti-nociceptive (analgesic) medicines. However, some new players in nociception have emerged only recently, for example mechanosensitive Piezo and the CRAC Orai1 channels. Moreover, the function of some ion channels, especially those which can counteract nociception, for instance, potassium K2P channels, is not well characterized. There are also gaps in understanding the role of ion channels in situ, ion channel interactions, functional role of sensitization-desensitization and ion channel inactivation, endogenous modulators and other important aspects of functioning of excitable nociceptive neurons and partnering non-excitable cells.

This Special Issue on 'Ion Channels of Nociception' aims to collect reviews and original papers devoted to elucidating the role of receptor- and voltage-gated ion channels in pain signaling. Together, these will shed light on the molecular mechanisms underlying the generation and propagation of nociceptive signals, supporting research into new pain therapies.

Prof. Dr. Rashid Giniatullin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • pain
  • nociception
  • molecular mechanisms
  • molecular structures
  • migraine
  • neuropathic pain
  • cancer pain
  • nociceptive neurons
  • voltage-gated ion channels
  • ligand-gated ion channels
  • analgesic drugs
  • mechanosensitive Piezo channels
  • CRAC Orai1 channels
  • K2P channels
  • sodium channels
  • sensitization
  • ion channel inactivation

Published Papers

This special issue is now open for submission.
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