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Advanced Research on Sulfatases and Sulfotransferases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (10 March 2024) | Viewed by 238

Special Issue Editor

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Guest Editor
Jesse Brown VA Medical Center, University of Illinois at Chicago, Chicago, IL 60612, USA
Interests: role of sulfatases and sulfotransferases in human diseases
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Special Issue Information

Dear Colleagues,

The identification of the roles played by sulfatases, sulfotransferase enzymes, and sulfated glycosaminoglycans (GAGs) in signaling, transcription, and cell differentiation has focused on the mechanisms of action in well-defined biological systems. Together, sulfatases, sulfotransferases, and sulfated GAGs confer remarkable specificity in the regulation of vital processes in plants, microbiota, and macrobiota. By the post-translational modification of carbohydrates, including glycosaminoglycans, lipids, proteins, and steroids, sulfation influences interactions within and between cells and in response to the extracellular environment. Thus, changes in sulfation affect subsequent phosphorylations and other post-translational events. The specific, chemically precise recognition signals attributable to localized sulfates can influence vital cell processes in immunity and host cell responses to infection, as well as in the activation/inactivation of steroid hormones, coagulation, drug metabolism, and cell signaling. The complex biochemistry required for the removal or addition of sulfate residues reflects the importance of molecular recognition and the potential harm of molecular mimicry, such as by the food additive carrageenan, to disrupt homeostatic mechanisms. The articles in this Special Issue will reveal the range of effects of sulfation, outline what is known about the underlying molecular and biochemical pathways, and suggest avenues for future investigations.

Dr. Joanne Tobacman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • sulfatase
  • sulfotransferase
  • heparin
  • chondroitin sulfate
  • sulfated glycosaminoglycans (GAGs)
  • sulfation

Published Papers

There is no accepted submissions to this special issue at this moment.
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