The Role of Primary Cell Line Models in Evolutionary Molecular Physiology
Deadline for manuscript submissions: 30 May 2024 | Viewed by 186
Interests: aging; endocrinology; comparative physiology; animal models; cell biology
Special Issues, Collections and Topics in MDPI journals
Primary cells are closest to the tissue of origin. They are taken directly from the tissue and processed to establish optimal culture conditions. Since they are tissue-derived and unmodified, they are more similar to the in vivo state and exhibit normal physiology. As such, they provide excellent model systems for studying the normal physiological and biochemical properties of cells (eg, metabolic studies, aging, signaling studies) and the effects of drugs and toxic compounds on cells.
Despite being the most direct approach, it is impractical to use intact vertebrates to ask questions about the evolution of physiological functions within and among populations of different species. In many cases, the individuals’ size and husbandry challenges (both known and unknown) make it unfeasible to use captive populations for study. On the other hand, using primary cell lines derived from any number of vertebrate species is an attractive model system for studying evolutionary physiology. Although primary fibroblasts are the most used cell type, others are amendable to this approach, for example, respiratory epithelial cells and myoblasts, and have been used to address the effect of exogenous factors or variation in the life history traits among species on cellular physiology.
For this Special Issue, reviews and research articles related to using primary cell lines to study the evolution of physiological function are welcome with a focus on the genetic, epigenetic, and molecular biochemistry underlying specific physiological processes. Moreover, we aimed to introduce different molecular methods of isolated Primary cells.
Dr. James M. Harper
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cell physiology
- comparative biology
- physiological ecology
- primary cell line