The Role of Primary Cell Line Models in Evolutionary Molecular Physiology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 May 2024 | Viewed by 226
Special Issue Editor
Interests: aging; endocrinology; comparative physiology; animal models; cell biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Primary cells are closest to the tissue of origin. They are taken directly from the tissue and processed to establish optimal culture conditions. Since they are tissue-derived and unmodified, they are more similar to the in vivo state and exhibit normal physiology. As such, they provide excellent model systems for studying the normal physiological and biochemical properties of cells (eg, metabolic studies, aging, signaling studies) and the effects of drugs and toxic compounds on cells.
Despite being the most direct approach, it is impractical to use intact vertebrates to ask questions about the evolution of physiological functions within and among populations of different species. In many cases, the individuals’ size and husbandry challenges (both known and unknown) make it unfeasible to use captive populations for study. On the other hand, using primary cell lines derived from any number of vertebrate species is an attractive model system for studying evolutionary physiology. Although primary fibroblasts are the most used cell type, others are amendable to this approach, for example, respiratory epithelial cells and myoblasts, and have been used to address the effect of exogenous factors or variation in the life history traits among species on cellular physiology.
For this Special Issue, reviews and research articles related to using primary cell lines to study the evolution of physiological function are welcome with a focus on the genetic, epigenetic, and molecular biochemistry underlying specific physiological processes. Moreover, we aimed to introduce different molecular methods of isolated Primary cells.
Dr. James M. Harper
Guest Editor
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Keywords
- cell physiology
- fibroblasts
- comparative biology
- evolution
- physiological ecology
- vertebrates
- primary cell line
